323591-16-8

Basic information

• Product Name: N-[1-(1H-1,2,3-benzotriazol-1-yl)-2,2-dichloropropyl]-3-chlorobenzamide
• Synonyms: N-[1-(1H-1,2,3-benzotriazol-1-yl)-2,2-dichloropropyl]-3-chlorobenzamide
• CAS NO: 323591-16-8
• Molecular Weight: 383.664
• Mol File: 323591-16-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: N-[1-(1H-1,2,3-benzotriazol-1-yl)-2,2-dichloropropyl]-3-chlorobenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[1-(1H-1,2,3-benzotriazol-1-yl)-2,2-dichloropropyl]-3-chlorobenzamide(323591-16-8)
• EPA Substance Registry System: N-[1-(1H-1,2,3-benzotriazol-1-yl)-2,2-dichloropropyl]-3-chlorobenzamide(323591-16-8)

Safety Data

• Hazardous Substances Data: 323591-16-8(Hazardous Substances Data)

Upstream product

• 95-14-7 1,2,3-Benzotriazole 
• 27313-32-2 2,2-dichloropropanal 
• 618-48-4 3-chlorobenzamide 

Relevant articles and documents

Structure-activity studies of novel cyanoguanidine ATP-sensitive potassium channel openers for the treatment of overactive bladder

A series of novel cyanoguanidine derivatives was designed and synthesized. Condensation of N-(1-benzotriazol-1-yl-2,2-dichloropropyl)-substituted benzamides with N-(substituted-pyridin-3-yl)-N′-cyanoguanidines furnished N-{2,2-dichloro-1-[N′-(substituted-pyridin-3-yl)-N′-cyanoguanidino] propyl}-substituted benzamide derivatives. These agents were glyburide-reversible potassium channel openers and hyperpolarized human bladder cells as assessed by the FLIPR membrane potential dye (KATP-FMP). These compounds were also potent full agonists in relaxing electrically stimulated pig bladder strips, an in vitro model of overactive bladder. The most active compound 9 was evaluated for in vivo efficacy and selectivity in a pig model of bladder instability. Preliminary pharmacokinetic studies in dog demonstrated excellent oral bioavailability and a t1/2 of 15 h. The synthesis, SAR studies, and biological properties of these agents are discussed.

Potassium channel openers

Compounds of formula I: are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.

Aminal Diones as potassium channel openers

Compounds of formula (I) 1may be useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.