323592-87-6Relevant academic research and scientific papers
Practical synthesis of 1-aryl-6-(hydroxymethyl)-2-ketopiperazines via a 6-exo amide-epoxide cyclization
Powell, Noel A.,Ciske, Fred L.,Clay, Emma C.,Cody, Wayne L.,Downing, Dennis M.,Blazecka, Peter G.,Holsworth, Daniel D.,Edmunds, Jeremy J.
, p. 4069 - 4072 (2004)
(Chemical Equation Presented) Chiral 1-aryl-6-(hydroxymethyl)-2- ketopiperazines can be prepared via an operationally simple, 6-exo epoxide ring-opening cyclization to form the ketopiperazine C6-N1 bond in high yields and with excellent enantiomeric purity.
PIPERAZINE DERIVATIVE RENIN INHIBITORS
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Page 68-69, (2010/02/09)
Disclosed are piperazine derivatives, their manufacture and use as inhibitors of renin. Formula (I):
