777934-57-3

Upstream product

• 19578-68-8 4-(4-benzyloxyphenyl) iodide 
• 777934-47-1 (3R)-3-hydroxymethyl-5-oxopiperazine-1-carboxylic acid tert-butyl ester 
• 100-39-0 benzyl bromide 
• 777934-43-7 (3R)-3-hydroxymethyl-4-(4-hydroxyphenyl)-5-oxopiperazine-1-carboxylic acid tert-butyl ester 
• 323592-89-8 (S)-4-formyl-2,2-dimethyl-3-oxazolidinecarboxylic acid tert-butyl ester 
• 323592-87-6 (6R)-4-benzyl-6-hydroxymethylpiperazin-2-one 

Downstream Products

• 777934-58-4 (5R)-4-(4-benzyloxyphenyl)-3-oxo-5-trifluoromethanesulfonyloxymethylpiperazine-1-carboxylic acid tert-butyl ester 
• 777934-43-7 (3R)-3-hydroxymethyl-4-(4-hydroxyphenyl)-5-oxopiperazine-1-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

PIPERAZINE DERIVATIVE RENIN INHIBITORS

Disclosed are piperazine derivatives, their manufacture and use as inhibitors of renin. Formula (I):

Practical synthesis of 1-aryl-6-(hydroxymethyl)-2-ketopiperazines via a 6-exo amide-epoxide cyclization

(Chemical Equation Presented) Chiral 1-aryl-6-(hydroxymethyl)-2- ketopiperazines can be prepared via an operationally simple, 6-exo epoxide ring-opening cyclization to form the ketopiperazine C6-N1 bond in high yields and with excellent enantiomeric purity.