32366-73-7

Upstream product

• 112-47-0 1,10-Decanediol 
• 124-63-0 methanesulfonyl chloride 

Downstream Products

• 16355-92-3 1,10-diiododecane 
• 81506-08-3 1,5,9,20,24,28-hexakis(p-tolylsulfonyl)-1,5,9,20,24,28-hexaazacyclooctatriacontane 
• 106961-24-4 N,N',4,8,19,23-hexakis(p-tolylsulfonyl)-4,8,19,23-tetraazahexaicosane-1,26-diamine 

Relevant academic research and scientific papers

Inhibition of bacterial growth and galactosyltransferase activity of WbwC by α, ω-bis(3-alkyl-1H-imidazolium)alkane salts: Effect of varying carbon content

A series of compounds was designed and synthesized having two imidazolium rings separated by a polymethylene spacer and having alkyl substituents on each of the imidazolium rings. The compounds were assayed for their effects on the activity of galactosyltransferase WbwC, and also on the growth of Gram-negative and Gram-positive bacteria, as well as human cells. The inhibition observed on enzyme activities and cell growth was dependent on the total number of carbons in the spacer and the alkyl substituents on the imidazolium rings. These readily synthesized, achiral compounds have potential as antimicrobial and antiseptic agents.

Linker compound and preparation method thereof

The present invention relates to a multipurpose linker compound. More specifically, the present invention relates to: a linker compound which can be labeled on a substrate surface of: a low molecular compound, a polymer compound, polymer nanoparticles, magnetic nanoparticles or quantum dots; a method of manufacturing the same; and an application of the same. The present invention provides a novel linker which can be used for various purposes. The linker according to the present invention can combine with a substrate of low molecules, polymers, polymer nanoparticles, quantum dots or magnetic nanoparticles, thereby modifying a surface or preventing an oxidation of the magnetic nanoparticle and improving reactivity with a target substance.COPYRIGHT KIPO 2019

Linker compound for imaging application

The present invention relates to an imaging linker compound which can be applied to an imaging composition by being combined with a dye or the like. The imaging linker compound is represented by chemical formula 1a. In chemical formula 1a, R is succinimidyloxyl or ethenesulfonylC_(1-6)alkylaminyl, A is C_(1-3)alkyleneoxyC_(1-3)alkylene, and n is an integer of 1 to 100.COPYRIGHT KIPO 2019

Linker compound and preparation method thereof

The present invention relates to a multipurpose linker compound represented by chemical formula 1. In the chemical formula 1, R1 is selected from halogen, succinimidyloxyl, ethene sulfonyl C_1-6 alkylaminyl, amino C_1-6 alkylaminyl, 4,6-dichloro-1,3,5-tri

BIVALENT BROMODOMAIN LIGANDS, AND METHODS OF USING SAME

Described herein are compounds capable of modulating one or more biomolecules substantially simultaneously, e.g., modulating two or more binding domains (e.g., bromodomains) on a protein or on different proteins. For example, in one aspect, a bivalent compound or a pharmaceutically acceptable salt, stereoisomer, metabolite, or hydrate thereof is provided. In another aspect, a method of treating a disease associated with a protein having tandem bromodomains in a patient in need thereof is provided. The method comprises administering to the patient the bivalent compound as described.

Catalytic nucleophilic fluorination by an imidazolium ionic liquid possessing trialkylphosphine oxide functionality

Abstract The synthesis of a new alkylmethylimidazolium ionic liquid wherein the alkyl group is functionalized with dihexylphosphine oxide moiety at the terminal position has been achieved in four steps from 1-methylimidazole. This hybrid ionic liquid effectively catalyzed the nucleophilic fluorination of primary alkyl mesylates under mild conditions using CsF as the fluoride source with a faster rate compared to butylmethylimidazolium mesylate. The hybrid catalyst was recycled 5 times without compromising the yield and purity of the product. The nucleophilic fluorination has been used for the synthesis of diethyl 2-(5-fluoropentyl)-2-methyl malonate, a precursor of 18F isotopomer of an apoptosis imaging agent and the protected form of O-(2'-fluoroethyl)-l-tyrosine, a 18F isotopomer of a tumor imaging agent.

Novel Ion Containing Liquid Crystals and Liquid Crystalline Main Chain Polymers Based on Trans-1,2-Bis(4-Pyridyl Ethylene) Mesogen

Ion bearing liquid crystalline compounds based on trans-1,2-bis(4-pyridinium)ethylene were synthesized and studied.These compounds included low molecular mass analogues, twin model compounds and main chain ionomers.Most of these exhibited liquid crystallinity of the smectic type.As a general rule the introduction of charges into the mesogenic moiety increased the stability (transition temperature) of the mesophase.Large supercooling effects, broad mesophase intervals and tendency to polymorphism are common features of these ionic mesogenic compounds.In the case of twin model compounds a variety of smectic phases were observed.The nature of these was dependent on the nature of the counterion and the thermal history of the compound.Tosylate or p.toluene sulfonate counterions promoted a higher degree of order in smectic mesophases as well as higher transition tempertures compared to methylsulfonate counterions.A pronounced odd-even effect of the isotropisation temperature of the twin compounds was observed.Compounds with even numbered methylene spacers display higher transition temperatures than those with an odd spacer.Only polymers with methylsulfonate and toluenesulfonate counterions were found to exhibit both, thermotropic and lyotropic mesophases.Thermotropic mesophases were characterized as smectic mesophases of lower order (SA).The nature of lyotropic mesophases were not determined.High transition temperatures and concommitant oxydative crosslinking made the study of polymers with halogen counterions difficult.Polymers with halogen and perchlorate counterions were found fo be poorly soluble in water precluding the formation of lyotropic mesophases.The introduction of a few siloxane bonds into the flexible spacer joining the charged mesogen moieties has a dramatic effect on lowering the transition temparatures and making possible the study of mesophases up to their isotropisation temperature.Preliminary characterization of polymers with siloxane containing spacer and methylsulfonate/tosylate counterions suggest a smectic mesophase of lower order. - Keywords: Ion containing liquid crystals, liquid crystal ionomers

Anion Coreceptor Molecules. Linear Molecular Recognition in the Selective Binding of Dicarboxylate Substrates by Ditopic Polyammonium Macrocycles

Three macrocyclic hexaamines 1,2, and 4 and the acyclic tetraamine 5 and hexaamine 6 have been synthesized.The hexaamines 1, 2, and 4 are ditopic coreceptor molecules containing two triamine subunits which may bind anionic substrates when protonated.The s

Composition and process for reducing the oily appearance of the hair and skin

A composition for treating oily hair or skin to reduce the oily appearance thereof comprises in an appropriate vehicle an active compound having the formula, STR1 wherein n is a whole number from 1-10 inclusive, p is 0, 1 or 2, and R1 is STR2 wherein R2 is STR3 or --CO2 H wherein R3 and R4 represent hydrogen, 2-hydroxy ethyl, 2-hydroxy propyl or 2,3-dihydroxy propyl; (iii) --(CH2 --CHR5) OH wherein R5 is hydrogen, methyl or hydroxy methyl; STR4 wherein R3 and R4 have the meanings given above; or (v) STR5 wherein q is 1 or 2 and A represents hydrogen, acyl, succinoyl, nictinoyl or thenoyl; with the proviso that p is other than 0 and n is other than 2-4 when R1 is (iv) or (v).