32367-75-2 Usage
General Description
Phenothiazine, 10-(2-(1-methyl-2-piperidyl)ethyl)- is a chemical compound that belongs to the phenothiazine class of drugs. It is commonly used as an antipsychotic medication to treat conditions such as schizophrenia and bipolar disorder. The compound works by blocking certain neurotransmitters in the brain, which helps to alleviate symptoms of psychosis and stabilize mood. Phenothiazine, 10-(2-(1-methyl-2-piperidyl)ethyl)- can also be used as an antiemetic to prevent nausea and vomiting. However, it may cause side effects such as drowsiness, dizziness, and dry mouth. It is important to follow the prescribed dosage and instructions when using this medication.
Check Digit Verification of cas no
The CAS Registry Mumber 32367-75-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,2,3,6 and 7 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 32367-75:
(7*3)+(6*2)+(5*3)+(4*6)+(3*7)+(2*7)+(1*5)=112
112 % 10 = 2
So 32367-75-2 is a valid CAS Registry Number.
InChI:InChI=1/C20H24N2S/c1-21-14-7-6-8-16(21)13-15-22-17-9-2-4-11-19(17)23-20-12-5-3-10-18(20)22/h2-5,9-12,16H,6-8,13-15H2,1H3
32367-75-2Relevant articles and documents
Synthesis and SAR evaluation of novel thioridazine derivatives active against drug-resistant tuberculosis
Scalacci, Nicolò,Brown, Alistair K.,Pavan, Fernando R.,Ribeiro, Camila M.,Manetti, Fabrizio,Bhakta, Sanjib,Maitra, Arundhati,Smith, Darren L.,Petricci, Elena,Castagnolo, Daniele
, p. 147 - 158 (2016/12/30)
The neuroleptic drug thioridazine has been recently repositioned as possible anti-tubercular drug. Thioridazine showed anti-tubercular activity against drug resistant mycobacteria but it is endowed with adverse side effects. A small library of thioridazine derivatives has been designed through the replacement of the piperidine and phenothiazine moieties, with the aim to improve the anti-tubercular activity and to reduce the cytotoxic effects. Among the resulting compounds, the indole derivative 12e showed an antimycobacterial activity significantly better than thioridazine and a cytotoxicity 15-fold lower.
