32367-75-2 Usage
Uses
Used in Pharmaceutical Industry:
Phenothiazine, 10-(2-(1-methyl-2-piperidyl)ethyl)is used as an antipsychotic medication for the treatment of psychiatric conditions such as schizophrenia and bipolar disorder. It functions by blocking specific neurotransmitters in the brain, which helps to reduce psychotic symptoms and stabilize mood swings.
Additionally, it is used as an antiemetic to prevent nausea and vomiting, providing relief for patients who suffer from these symptoms due to various causes.
However, it is important to note that Phenothiazine, 10-(2-(1-methyl-2-piperidyl)ethyl)may cause side effects such as drowsiness, dizziness, and dry mouth. Therefore, it is crucial to adhere to the prescribed dosage and follow the instructions provided by healthcare professionals to ensure safe and effective use of this medication.
Check Digit Verification of cas no
The CAS Registry Mumber 32367-75-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,2,3,6 and 7 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 32367-75:
(7*3)+(6*2)+(5*3)+(4*6)+(3*7)+(2*7)+(1*5)=112
112 % 10 = 2
So 32367-75-2 is a valid CAS Registry Number.
InChI:InChI=1/C20H24N2S/c1-21-14-7-6-8-16(21)13-15-22-17-9-2-4-11-19(17)23-20-12-5-3-10-18(20)22/h2-5,9-12,16H,6-8,13-15H2,1H3
32367-75-2Relevant academic research and scientific papers
Synthesis and SAR evaluation of novel thioridazine derivatives active against drug-resistant tuberculosis
Scalacci, Nicolò,Brown, Alistair K.,Pavan, Fernando R.,Ribeiro, Camila M.,Manetti, Fabrizio,Bhakta, Sanjib,Maitra, Arundhati,Smith, Darren L.,Petricci, Elena,Castagnolo, Daniele
, p. 147 - 158 (2016/12/30)
The neuroleptic drug thioridazine has been recently repositioned as possible anti-tubercular drug. Thioridazine showed anti-tubercular activity against drug resistant mycobacteria but it is endowed with adverse side effects. A small library of thioridazine derivatives has been designed through the replacement of the piperidine and phenothiazine moieties, with the aim to improve the anti-tubercular activity and to reduce the cytotoxic effects. Among the resulting compounds, the indole derivative 12e showed an antimycobacterial activity significantly better than thioridazine and a cytotoxicity 15-fold lower.
