32381-30-9Relevant academic research and scientific papers
Straightforward Functionalization of Sulfur-Containing Peptides via 5- And 6- endo - Dig Cyclization Reactions
Lapcinska, Sindija,Arsenyan, Pavel
, p. 1805 - 1820 (2021)
We present a simple and convenient method for the generation of sulfenyl electrophiles from peptides containing S-S or S-H bonds by employing N -chlorosuccinimide. The corresponding sulfenyl electrophiles are further utilized in 5- and 6- endo - dig cyclization reactions yielding indolizinium salts, indoles, benzo[ b ]furans, polyaromatic hydrocarbons (PAHs) and isocoumarins, as well as quinolinones bearing a glutathione moiety. PAH derivatives can be used as selective fluorescent dyes for the visualization of lipid droplets in living cells.
