32382-57-3

Basic information

• Product Name: 1-(2,2-difluoroethyl)-4-nitrobenzene
• Synonyms: 1-(2,2-difluoroethyl)-4-nitrobenzene
• CAS NO: 32382-57-3
• Molecular Weight: 187.146
• Mol File: 32382-57-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-(2,2-difluoroethyl)-4-nitrobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,2-difluoroethyl)-4-nitrobenzene(32382-57-3)
• EPA Substance Registry System: 1-(2,2-difluoroethyl)-4-nitrobenzene(32382-57-3)

Safety Data

• Hazardous Substances Data: 32382-57-3(Hazardous Substances Data)

Upstream product

• 555-16-8 4-nitrobenzaldehdye 
• 100-13-0 4-nitrostyrene 
• 6388-74-5 p-Nitrophenyloxirane 

Downstream Products

• 22332-67-8 (E)-4-(2-fluorovinyl)nitrobenzene 

Relevant articles and documents

Enantioselective, Catalytic Vicinal Difluorination of Alkenes

The enantioselective, catalytic vicinal difluorination of alkenes is reported by II/IIII catalysis using a novel, C2-symmetric resorcinol derivative. Catalyst turnover via in situ generation of an ArIIIIF2 species is enabled by Selectfluor oxidation and addition of an inexpensive HF–amine complex. The HF:amine ratio employed in this process provides a handle for regioselective orthogonality as a function of Br?nsted acidity. Selectivity reversal from the 1,1-difluorination pathway (geminal) to the desired 1,2-difluorination (vicinal) is disclosed (>20:1 in both directions). Validation with electron deficient styrenes facilitates generation of chiral bioisosteres of the venerable CF3 unit that is pervasive in drug discovery (20 examples, up to 94:06 e.r.). An achiral variant of the reaction is also presented using p-TolI (up to >95 % yield).