6388-74-5

Basic information

• Product Name: (p-nitrophenyl)oxirane
• Synonyms: (p-nitrophenyl)oxirane;4-nitrostyrene oxide;(4-Nitrophenyl)oxirane;1-(Oxiranyl)-4-nitrobenzene;1-Nitro-4-oxiranylbenzene;4-Nitrophenyloxirane;1-(Epoxyethyl)-4-nitrobenzene;1,2-Epoxy-1-(p-nitrophenyl)ethane
• CAS NO: 6388-74-5
• Molecular Formula: C₈H₇NO₃
• Molecular Weight: 165.14608
• EINECS: 228-998-5
• Mol File: 6388-74-5.mol
• Article Data: 106

Chemical Properties

• Boiling Point: 302.7°C at 760 mmHg
• Flash Point: 158°C
• Appearance: /
• Density: 1.372g/cm³
• Vapor Pressure: 0.00175mmHg at 25°C
• Refractive Index: 1.611
• CAS DataBase Reference: (p-nitrophenyl)oxirane(CAS DataBase Reference)
• NIST Chemistry Reference: (p-nitrophenyl)oxirane(6388-74-5)
• EPA Substance Registry System: (p-nitrophenyl)oxirane(6388-74-5)

Safety Data

• Hazardous Substances Data: 6388-74-5(Hazardous Substances Data)

Usage

General Description

(p-nitrophenyl)oxirane, also known as p-nitrophenyl epoxide, is a chemical compound with the molecular formula C9H7NO3. It is a highly reactive epoxide that is commonly used as a reagent in organic synthesis. Its primary use is in the formation of chiral auxiliaries and as a precursor to a variety of other compounds. It is a pale yellow solid at room temperature and is typically handled and stored under inert gas due to its sensitivity to moisture and air. (p-nitrophenyl)oxirane is also known for its potential mutagenic and toxic properties, and proper handling procedures and safety precautions should be followed when working with this compound.

InChI:InChI=1/C8H7NO3/c10-9(11)7-3-1-6(2-4-7)8-5-12-8/h1-4,8H,5H2

Upstream product

• 100-13-0 4-nitrostyrene 
• 2039-85-2 3-Chlorostyrene 
• 555-16-8 4-nitrobenzaldehdye 
• 2181-42-2 trimethylsulphonium iodide 
• 1774-47-6 trimethylsulfoxonium iodide 
• 99-81-0 4-Nitrophenacyl bromide 
• 77-78-1 dimethyl sulfate 
• 6388-74-5 p-Nitrophenyloxirane 
• 19922-82-8 2-bromo-1-(4-nitrophenyl)ethanol 
• 902259-32-9 2-bromo-1-(4-nitrophenyl)ethanol 
• 78354-90-2 Methyl(phenyl)selenoniomethanid 
• 1073-67-2 4-vinylbenzyl chloride 
• 186581-53-3 diazomethane 
• 623-47-2 propynoic acid ethyl ester 

Downstream Products

• 100143-74-6 N-(β-hydroxy-4-nitro-phenethyl)-succinimide 
• 92868-81-0 2-(2-hydroxy-2-(4-nitro-phenyl)-ethyl)-isoindole-1,3-dione 
• 412274-38-5 1-(4-nitro-phenyl)-2-phenoxy-ethanol 
• 100-27-6 2-(4-nitrophenyl)ethanol 
• 77977-75-4 p-nitrophenylethylene glycol 
• 88057-20-9 4-[2-Hydroxy-1-(4-nitro-phenyl)-ethoxy]-butan-1-ol 
• 52090-00-3 1-[2-hydroxy-2-(4-nitro-phenyl)-ethyl]-pyridinium 
• 2010-59-5 1-(1,2-dichloroethyl)-4-nitrobenzene 
• 32382-57-3 1-(2,2-difluoroethyl)-4-nitrobenzene 
• 6388-74-5 (S)-2-(4-nitrophenyl)oxirane 
• 77977-74-3 (S)-(+)-1-(4-nitrophenyl)-1,2-ethanediol 
• 77977-74-3 (R)-(-)-1-(4-nitrophenyl)-1,2-ethanediol 

Relevant articles and documents

SUBSTITUTED PYRAZOLE COMPOUNDS AS TOLL RECEPTOR INHIBITORS

Disclosed are compounds of Formula (I) N-oxides, or salts thereof, wherein G, A, R1, and R5 are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.

Facile synthesis of libraries of functionalized cyclopropanes and oxiranes using ionic liquids – A new approach to the classical Corey-Chaykovsky reaction

The potential of [PAIM][NTf2]/BMIM-ILs as a base/solvent in the Corey-Chaykovsky reaction is demonstrated by the facile synthesis of libraries of functionalized cyclopropanes from enones and oxiranes from aldehydes and ketones, at room temperature in respectable isolated yields. To demonstrate their application, the synthesized epoxides were employed as substrates for the synthesis of a library of 2,3-disubstituted quinolines, using [BMIM(SO3H)][OTf]/[BMIM][PF6] as a catalyst/solvent. The potential for recycling/reuse of the IL solvents was also explored.

SUBSTITUTED INDOLE COMPOUNDS USEFUL AS TLR INHIBITORS

Disclosed are compounds of Formula (I) N-oxides, or salts thereof, wherein G, A, R1, R5, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.