32382-66-4

Upstream product

• 109-86-4 2-methoxy-ethanol 
• 62-53-3 aniline 
• 703-56-0 N-phenyl-2-oxazolidinone 
• 124-41-4 sodium methylate 
• 10312-83-1 methoxyacetaldehyde 
• 591-50-4 iodobenzene 
• 109-85-3 2-methoxyethylamine 
• 108-86-1 bromobenzene 
• 98-80-6 phenylboronic acid 
• 3747-48-6 1-chloro-2-phenylcarbamoyloxy-ethane 
• 111-95-5 Bis-(2-methoxyethyl)amine 
• 24388-23-6 2-phenyl-4,4,5,5-tetramethyl-1,3,2-dioxoborole 
• 6482-24-2 2-Bromoethyl methyl ether 
• 81090-01-9 [N-(2-methoxyethyl)-N-methyl]aniline 

Downstream Products

• 100141-33-1 N-(2-chloro-allyl)-N-(2-methoxy-ethyl)-aniline 
• 70039-84-8 {3-[(2-Methoxy-ethyl)-phenyl-carbamoyloxy]-phenyl}-carbamic acid ethyl ester 
• 70039-86-0 {3-[(2-Methoxy-ethyl)-phenyl-carbamoyloxy]-phenyl}-carbamic acid isopropyl ester 
• 70039-87-1 {3-[(2-Methoxy-ethyl)-phenyl-carbamoyloxy]-phenyl}-carbamic acid sec-butyl ester 
• 70040-51-6 {3-[(2-Methoxy-ethyl)-phenyl-carbamoyloxy]-phenyl}-carbamic acid 2-chloro-1-methyl-ethyl ester 
• 70040-14-1 (2-Methoxy-ethyl)-phenyl-carbamic acid 3-methylsulfanylcarbonylamino-phenyl ester 
• 70039-81-5 N-(2-Methoxyethyl)-carbanilic acid-(3-methoxy carbonylamino)-phenyl-ester 
• 70039-96-2 (2-Methoxy-ethyl)-phenyl-carbamic acid 3-ethylsulfanylcarbonylamino-phenyl ester 
• 70039-89-3 {3-[(2-Methoxy-ethyl)-phenyl-carbamoyloxy]-phenyl}-carbamic acid isobutyl ester 
• 70039-90-6 {3-[(2-Methoxy-ethyl)-phenyl-carbamoyloxy]-phenyl}-carbamic acid allyl ester 
• 70039-93-9 {3-[(2-Methoxy-ethyl)-phenyl-carbamoyloxy]-phenyl}-carbamic acid prop-2-ynyl ester 
• 105340-37-2 N-(2-chloro-allyl)-N-(2-methoxy-ethyl)-4-nitroso-aniline 
• 32382-80-2 N-(β-Methoxyaethyl)-formanilid 
• 103867-28-3 3-Cyclohexyl-N-(2-methoxy-ethyl)-N-phenyl-propionamide 

Relevant academic research and scientific papers

Efficient methylation of anilines with methanol catalysed by cyclometalated ruthenium complexes

Cyclometalated ruthenium complexes4-10allow the effective methylation of anilines with methanol to selectively giveN-methylanilines. This hydrogen autotransfer procedure proceeds under mild conditions (60 °C) in a practical manner (NaOH as base). Mechanistic investigations suggest an active homogenous ruthenium complex and β-hydride elimination of methanol as the rate determining step.

DIACYLGLYCEROL KINASE MODULATING COMPOUNDS

The present disclosure provides diacylglycerol kinase modulating compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection. The compounds can be used alone or in combination with other agents.

Catalyst-free photoinduced selective oxidative C(sp3)-C(sp3) bond cleavage in arylamines

Due to the directional nature of sp3-hybridized orbitals and the absence of π-orbitals, the oxidative cleavage of the kinetically and thermodynamically stable C(sp3)-C(sp3) bond is extremely difficult and remains scarcely explored. In this work, under the double argument of quantum mechanics (QM) computations and meticulous experiments on our well-designed C-C single bond cleavage mechanism, we discovered a means of photoinduced selective oxidative C(sp3)-C(sp3) bond cleavage in arylamines, easily achieved by simple visible light irradiation using O2as a benign oxidant under very mild conditions. The utility of our methodology was demonstrated by the C(sp3)-C(sp3) bond cleavage in morpholine/piperazine arylamines with excellent functional group tolerance. Importantly, our methodology is noteworthy, not only in that it does not require any catalysts, but also in that it provides valuable possibilities for the scalable functionalization of clinical drugs and natural products.

USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND COMPOSITIONS COMPRISING SUCH ACTIVE INGREDIENTS

The invention relates primarily to a method of modulation, preferably of in vitro and/or in vivo modulation, of the cold menthol receptor TRPM8, wherein the receptor is contacted with at least one modulator selected from the group consisting of the compounds of the structure type 1 described herein. The present invention further relates to corresponding uses and compositions comprising such compounds.

Chan-Evans-Lam Amination of Boronic Acid Pinacol (BPin) Esters: Overcoming the Aryl Amine Problem

The Chan-Evans-Lam reaction is a valuable C-N bond forming process. However, aryl boronic acid pinacol (BPin) ester reagents can be difficult coupling partners that often deliver low yields, in particular in reactions with aryl amines. Herein, we report effective reaction conditions for the Chan-Evans-Lam amination of aryl BPin with alkyl and aryl amines. A mixed MeCN/EtOH solvent system was found to enable effective C-N bond formation using aryl amines while EtOH is not required for the coupling of alkyl amines.

Synchronizing steric and electronic effects in {RuII(NNNN,P)} complexes: The catalytic dehydrative alkylation of anilines by using alcohols as a case study

A series of new hexacoordinated {RuII(NNNN,P)} complexes was prepared from [RuCl2(R3P)3]. Their structure was determined by X-ray crystallography. The catalytic potential of this new class of complexes was tested in the alkylation of aniline with benzyl alcohol. In this test reaction, the influence of the counteranion plus electronic influences at the tetradentate ligand and the phosphine ligand were examined. The electrochemistry of all complexes was studied by cyclic voltammetry. Depending on the substituent at the ligand backbone, the complexes showed a different behavior. For all N-benzyl substituted complexes, reversible Ru II/III redox potentials were observed, whereas the N-methyl substituted complex possessed an irreversible oxidation event at small scan rates. Furthermore, the electronic influence of different substituents at the ligand scaffold and at the phosphine on the RuII/III redox potential was investigated. The measured E0 values were correlated to the theoretically determined HOMO energies of the complexes. In addition, these HOMO energies correlated well with the reactivity of the single complexes in the alkylation of aniline with benzyl alcohol. The exact balance of redox potential and reactivity appears to be crucial for synchronizing the multiple hydrogen-transfer events. The optimized catalyst structure was applied in a screening on scope and limitation in the catalytic dehydrative alkylation of anilines by using alcohols.

Ligand-free iron/copper cocatalyzed N-arylations of aryl halides with amines under microwave irradiation

Ligand-free iron/copper cocatalyzed cross-coupling reactions of aryl halides with amines were carried out to provide the corresponding coupling products in good yields. It is worth noting that the method displays a broad substrate scope, and is convenient, rapid, low-cost and environmentally friendly.

N-Dealkylation of aliphatic amines and selective synthesis of monoalkylated aryl amines

Highly selective alkyl transfer processes of mono-, di- and trialkyl amines in the presence of the Shvo catalyst have been realized; in addition, a general method for N-alkylation of aniline with di- and trialkyl amines is presented. The Royal Society of Chemistry.

A fully integrated high-throughput screening methodology for the discovery of new polyolefin catalysts: Discovery of a new class of high temperature single-site group (IV) copolymerization catalysts

For the first time, new catalysts for olefin polymerization have been discovered through the application of fully integrated high-throughput primary and secondary screening techniques supported by rapid polymer characterization methods. Microscale 1-octene primary screening polymerization experiments combining arrays of ligands with reactive metal complexes M(CH2Ph)4 (M = Zr, Hf) and multiple activation conditions represent a new high-throughput technique for discovering novel group (IV) polymerization catalysts. The primary screening methods described here have been validated using a commercially relevant polyolefin catalyst, and implemented rapidly to discover the new amide-ether based hafnium catalyst [η2- (N,O)-(2-MeO-C6H4) (2,4,6-Me3C6H2)N]Hf (CH2Ph)3 (1), which is capable of polymerizing 1-octene to high conversion. The molecular structure of 1 has been determined by X-ray diffraction. Larger scale secondary screening experiments performed on a focused 96-member amine-ether library demonstrated the versatile high temperature ethylene-1-octene copolymerization capabilities of this catalyst class, and led to significant performance improvements over the initial primary screening discovery. Conventional one gallon batch reactor copolymerizations performed using selected amide-ether hafnium compounds confirmed the performance features of this new catalyst class, serving to fully validate the experimental results from the high-throughput approaches described herein.

Ligand- and Base-Free Copper(II)-Catalyzed C-N Bond Formation: Cross-Coupling Reactions of Organoboron Compounds with Aliphatic Amines and Anilines

(Equation presented) A ligandless and base-free Cu-catalyzed protocol for the cross-coupling of arylboronic acids and potassium aryltrifluoroborate salts with primary and secondary aliphatic amines and anilines is described. The process utilizes catalytic copper(II) acetate monohydrate and 4 A molecular sieves in dichloromethane at slightly elevated temperatures under an atmosphere of oxygen. A broad range of functional groups are tolerated on both of the cross-coupling partners.