32385-30-1

Basic information

• Product Name: 3-(2-naphthylsulfonyl)propanoic acid
• Synonyms: 3-(2-naphthylsulfonyl)propanoic acid;propanoic acid, 3-(2-naphthalenylsulfonyl)-;3-(2-naphthylsulfonyl)propionic acid;3-naphthalen-2-ylsulfonylpropanoic acid
• CAS NO: 32385-30-1
• Molecular Formula: C13H12O4S
• Molecular Weight: 264.3
• Mol File: 32385-30-1.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 548.7±42.0 °C(Predicted)
• Appearance: /
• Density: 1.369±0.06 g/cm3(Predicted)
• PKA: 3.77±0.10(Predicted)
• CAS DataBase Reference: 3-(2-naphthylsulfonyl)propanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-naphthylsulfonyl)propanoic acid(32385-30-1)
• EPA Substance Registry System: 3-(2-naphthylsulfonyl)propanoic acid(32385-30-1)

Safety Data

• Hazardous Substances Data: 32385-30-1(Hazardous Substances Data)

Upstream product

• 1141-45-3 3-(naphthalen-2-ylsulfanyl)-propanoic acid 
• 100727-35-3 3-(naphthalene-2-sulfonyl)-propionitrile 

Relevant articles and documents

MODERN FRIEDEL-CRAFTS CHEMISTRY. XI. CYCLIZATION OF ARYL HALOALKYL SULFONES, ARYLSULFONYLACYL CHLORIDES AND THEIR CORRESPONDING SULFIDES

The sulfone group deactivation for cyclialkylation and cycliacylation reactions in the presence of Friedel-Crafts catalysts was demonstrated in a number of aryl chloroalkylsulfones (1-8) and arylsulfonylacyl chlorides (17a-22a), respectively.As expected, the corresponding arylchloroalkyl sulfides (9-16) and arylmercaptoacyl chlorides (13a-28a) underwent ring-closure reaction in most cases under the same conditions.The ease of cyclization was governed by the ring size, the stability of the attacking carbocation and the nucleophilicity of the aryl moiety.Also, the behaviour of benzyl sulfones (29, 31a, and 32a) and sulfides (33, 34a and 36a) was inconsistent.Noteworthy, the Friedel-Crafts cyclization reaction is thus considered an accessible method for the synthesis of compounds 37-41 and 45, 51.