32387-01-2

Usage

Molecular structure

The compound has an isoindole-1,3(2H)-dione core structure with a cyclohexa-2,4-dien-1-ylidene moiety and an amino group attached to a methyl group.

Biological and pharmaceutical applications

The compound has potential as an anti-cancer, anti-inflammatory, and anti-microbial agent.

Enzyme and pathway inhibition

The compound has been shown to inhibit certain enzymes and pathways involved in cancer cell proliferation and survival.

Further research needed

More research is needed to fully understand the pharmacological and biological activities of 2-{[(6-oxocyclohexa-2,4-dien-1-ylidene)methyl]amino}-1H-isoindole-1,3(2H)-dione and its potential as a therapeutic agent.

Upstream product

• 1875-48-5 N-aminophthalamide 
• 90-02-8 salicylaldehyde 

Downstream Products

• 71271-35-7 4-(2-methoxy-phenyl)-2H-phthalazin-1-one 
• 93517-77-2 4-m-tolylphthalazin-1(2H)-one 

Relevant academic research and scientific papers

Synthesis, characterization, antimicrobial, DNA binding, and oxidative cleavage activities of Cu(II) and Co(II) complexes with 2-(2- hydroxybenzylideneamino)isoindoline-1,3-dione

(E)-2-(2-hydroxybenzylideneamino)isoindoline-1,3-dione (Hbid) was prepared by condensation of N-aminophthalimide and salicylaldehyde and characterized by elemental analysis, IR, 1H-NMR, and mass spectral studies. Mononuclear complexes [(phen)Cu

Action of Grignard Reagents and Amines on Some N-(Arylmethyleneamino)phthalimides

N-(Arylmethyleneamino)phthalimides (2a-c) carrying an o-substituent in the aryl group were prepared by the reaction of N-aminophthalimide with o-substituted benzaldehydes.The reaction of these compounds with Grignard reagents proceeded either by normal addition to one of the carbonyl groups to give 3a-c or by addition and cleavage to give 4-arylphthalaz-1-ones 5a-c.The steric effect exhibited by either the Grignard reagent or the N-arylmethylene compound was studied.The reaction of N-furfurylideneaminophthalimide (2d) with Grignard reagents was also investigated.N-( Arylmethyleneamino)phthalimides reacted with primary amines to give N,N'-dialkylphthalamides (7a and b) while the reaction with secondary amines gave (8a and b).

Studies in Antifertility Agents : Part XXXVI-Syntheses of N-(Substituted benzylidene)amino-phthalimides, -dihydroisoindoles and -1,2,3,4-tetrahydroisoquinolines

Syntheses and antifertility activity of a number of N-(substituted benzylidene)amino-phthalimides (3a-i), -dihydroisoindoles (4a-i) and -1,2,3,4-tetrahydroisoquinolines (5a-i) are reported.Some of these compounds prevent pregnancy when administered at 25 mg/kg/day in mice. 100percent abortifacient actvity has been shown by some of these compounds in rats at 20 mg/kg.