71271-35-7Relevant academic research and scientific papers
Synthesis of 1,2-dihydro-1-oxophthalazin-4-yl trifluoromethanesulfonate and its application in the synthesis of 4-(aryl/heteroaryl/alkynyl)phthalazin-1(2H)-one
Dhage, Ganesh Raosaheb,Deshmukh, Santosh Rangnath,Thopate, Shankar Ramchandra
, p. 33377 - 33384 (2015/04/27)
The regioselective synthesis of 1,2-dihydro-1-oxophthalazin-4-yl trifluoromethanesulfonate (3a) has been reported. The reaction of Tf2O (2a) with phthalhydrazide (1a) provides a rapid access to 3a with an excellent yield and a high level of reg
SYNTHESIS AND BEHAVIOUR OF N-NAPHTHYLMETHYLENEAMINOPHTHALIMIDES TOWARD NUCLEOPHILIC REAGENTS
Kandile, Nadia Gharib
, p. 533 - 538 (2007/10/02)
The reactions of N-naphthylmethyleneaminophthalimides (1a, b) with Grignard reagents took place either by normal addition to one of the carbonyl groups to give 2a, d, or by 1,2-addition and cleavage to give 4-arylphthalaz-1-ones (4a-d).The reactions of 1a, b with amines gave 5, 6 and 7, respectively.
Action of Grignard Reagents and Amines on Some N-(Arylmethyleneamino)phthalimides
Ismail, M. Fekry,El-Bassiouny, F. A.,Enayat, E. I.,Kaddah, A. M.,Younes, H. A.
, p. 177 - 182 (2007/10/02)
N-(Arylmethyleneamino)phthalimides (2a-c) carrying an o-substituent in the aryl group were prepared by the reaction of N-aminophthalimide with o-substituted benzaldehydes.The reaction of these compounds with Grignard reagents proceeded either by normal addition to one of the carbonyl groups to give 3a-c or by addition and cleavage to give 4-arylphthalaz-1-ones 5a-c.The steric effect exhibited by either the Grignard reagent or the N-arylmethylene compound was studied.The reaction of N-furfurylideneaminophthalimide (2d) with Grignard reagents was also investigated.N-( Arylmethyleneamino)phthalimides reacted with primary amines to give N,N'-dialkylphthalamides (7a and b) while the reaction with secondary amines gave (8a and b).
NEW CONVENIENT ONE-STEP SYNTHESIS OF 4-ARYLPHTHALAZ-1-ONES
Ismail, M. Fekry,El-Bassiouny, F. A.,Younes, H. A.
, p. 2983 - 2984 (2007/10/02)
4-Arylphthalaz-1-ones (2a-e) are prepared by the hitherto unknown reaction of N-aminophthalimide (1) with aromatic hydrocarbons under Friedel-Crafts conditions.The reaction of N-aminophthalimide with Grignard reagents presents another convenient method for the synthesis of 4-alkyl or 4-arylphthalaz-1-ones.
