324-32-3

Basic information

• Product Name: 2-Methyl-7-(trifluoroMethyl)quinoline
• Synonyms: 2-Methyl-7-(trifluoroMethyl)quinoline;N-(4-IODO-2-PYRIDINYL)ACETAMIDE
• CAS NO: 324-32-3
• Molecular Formula: C₁₁H₈F₃N
• Molecular Weight: 211.1831296
• Mol File: 324-32-3.mol

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-Methyl-7-(trifluoroMethyl)quinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methyl-7-(trifluoroMethyl)quinoline(324-32-3)
• EPA Substance Registry System: 2-Methyl-7-(trifluoroMethyl)quinoline(324-32-3)

Safety Data

• Hazardous Substances Data: 324-32-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Methyl-7-(trifluoroMethyl)quinoline is used as a building block for the synthesis of various drugs and pharmaceutical compounds. Its unique structure allows for the development of new drug candidates with potential therapeutic applications.
Used in Organic Chemistry:
2-Methyl-7-(trifluoroMethyl)quinoline is used as a reagent for various organic transformations and reactions. Its presence in these processes contributes to the advancement of chemical synthesis methodologies.
Used in Biological Research:
2-Methyl-7-(trifluoroMethyl)quinoline has been studied for its potential biological activities, including anti-inflammatory and antifungal properties. This research may lead to the discovery of new therapeutic agents for treating various conditions.

Upstream product

• 98-16-8 3-trifluoromethylaniline 
• 123-73-9 crotonaldehyde 
• 402-13-1 2-amino-4-trifluoromethylbenzoic acid 
• 186602-93-7 [2-amino-4-(trifluoromethyl)phenyl]methan-1-ol 
• 123-42-2 4-Hydroxy-4-methyl-2-pentanone 
• 109466-88-8 2-amino-4-(trifluoromethyl)benzaldehyde 
• 4784-77-4 (E)-1-Bromo-2-butene 
• 588-00-1 1,2-bis(3-(trifluoromethyl)phenyl)diazene 
• 123-73-9 trans-Crotonaldehyde 

Downstream Products

• 168083-09-8 3-(7-trifluoromethyl-2-quinolinylmethoxy)aniline 
• 475098-86-3 2-methylquinoline-7-carboxylic acid 
• 168083-34-9 2-(bromomethyl)-7-(trifluoromethyl)quinoline 

Relevant articles and documents

Design, synthesis, and antibacterial evaluation of PFK-158 derivatives as potent agents against drug-resistant bacteria

Infections caused by antibiotic resistant bacteria are a major health concern throughout the world. It is well known that PFK-158 can enhance the antibacterial effect of polymyxin, but its own anti-bactericidal effect is rarely discussed. In order to inve

Synthesis of quinolines and naphthyridines: Via catalytic retro-aldol reaction of β-hydroxyketones with ortho -aminobenzaldehydes or nicotinaldehydes

A Cu(i)-catalyzed retro-aldol reaction of β-hydroxyketones with ortho-aminobenzaldehydes and nicotinaldehydes is reported that produces a range of quinolines and naphthyridines with high efficiency and selectivity. This reaction uses β-hydroxyketones as a regiospecific ketone-protected enolate source via copper-catalyzed retro-aldol Cα-Cβ bond cleavage. The in situ generated copper enolate undergoes kinetically favorable cyclization with ortho-amino aryl aldehydes to produce quinolines and naphthyridines in a chemo- and regioselective manner. The mild and weakly basic reaction conditions also suppress possible side reactions of benzaldehydes under strongly basic conditions, resulting in improved reaction yields.

Copper-Promoted Tandem Reaction of Azobenzenes with Allyl Bromides via N=N Bond Cleavage for the Regioselective Synthesis of Quinolines

A copper-promoted tandem reaction of a variety of azobenzenes and allyl bromides via N=N bond cleavage to regioselectively construct quinoline derivatives has been developed. The azobenzenes act as not only construction units but also an oxidant for quinoline formation.

TRIAZOLOPYRIDINE COMPOUNDS AS PIM KINASE INHIBITORS

Compounds of Formula I: in which R1, R2, R3, R4 and R10 have the meanings given in the specification, are receptor tyrosine inhibitors useful in the treatment of diseases mediated by PIM-1 and/or PIM-2 and/or PIM-3 kinases.

Use of the Kohonen neural network for rapid screening of ex vivo anti-HIV activity of styrylquinolines

Using the Kohonen neural network, the electrostatic potentials on the molecular surfaces of 14 styrylquinoline derivatives were drawn as comparative two-dimensional maps and compared with their known human immunodeficiency virus (HIV)-1 replication blocki