324-57-2

Usage

Uses

Used in Research and Laboratory Settings:
2-(3-fluorophenyl)-5-phenyloxazole is used as a fluorescent dye for various biological and chemical studies. Its fluorescence properties allow researchers to track and visualize specific molecules or cellular structures, aiding in the understanding of complex biological processes and chemical reactions.
Used in Pharmaceutical Synthesis:
In the pharmaceutical industry, 2-(3-fluorophenyl)-5-phenyloxazole is utilized as a key intermediate in the synthesis of various organic compounds and drugs. Its unique structure and properties contribute to the development of new therapeutic agents with potential applications in treating a range of medical conditions.
Used in Chemical Research:
2-(3-fluorophenyl)-5-phenyloxazole is also employed in chemical research as a fluorescent tag. This allows chemists to study the behavior of different molecules and monitor reactions more effectively, leading to advancements in the field of organic chemistry.
It is crucial to handle 2-(3-fluorophenyl)-5-phenyloxazole with care and follow proper safety protocols to minimize any potential health and environmental risks associated with its use.

InChI:InChI=1/C15H10FNO/c16-13-8-4-7-12(9-13)15-17-10-14(18-15)11-5-2-1-3-6-11/h1-10H

Upstream product

• 455-37-8 3-fluorobenzamide 
• 122-78-1 phenylacetaldehyde 
• 304882-57-3 3-fluoro-N-(2-phenylethyl)benzamide 
• 1427180-46-8 3-fluoro-N-(pivaloyloxy)benzamide 
• 536-74-3 phenylacetylene 
• 1006-68-4 5-phenyloxazole 
• 1121-86-4 1-Fluoro-3-iodobenzene 
• 100-82-3 (3-fluorophenyl)methanamine 
• 614-47-1 1,3-diphenyl-propen-3-one 

Relevant academic research and scientific papers

Synthesis of 2,5-disubstituted oxazoles: Via cobalt(III)-catalyzed cross-coupling of N -pivaloyloxyamides and alkynes

An efficient synthesis of 2,5-disubstituted oxazoles via Co(iii) catalysis is described herein. The synthesis is achieved under mild conditions through [3+2] cycloaddition of N-pivaloyloxyamides and alkynes. The reaction operates through an internal oxidation pathway and features a very broad substrate scope. The one-step synthesis of natural products such as texamine and balsoxin has been demonstrated via this protocol.

Photoinduced Copper-Catalyzed C-H Arylation at Room Temperature

Room-temperature azole C-H arylations were accomplished with inexpensive copper(I) compounds by means of photoinduced catalysis. The expedient copper catalysis set the stage for site-selective C-H arylations of non-aromatic oxazolines under mild reaction conditions, and provides step-economical access to the alkaloid natural products balsoxin and texamine. Copper light: Room-temperature C-H arylations of heteroarenes were accomplished with inexpensive copper compounds by photoinduced catalysis. The expedient copper catalysis leads to site-selective C-H arylations of non-aromatic oxazolines under mild reaction conditions, and provides step-economical access to the alkaloid natural products balsoxin and texamine.

Iodine catalysed intramolecular C(sp3)-H functionalization: synthesis of 2,5-disubstituted oxazoles from N-arylethylamides

Iodine catalyzed synthesis of 2,5-disubstituted oxazoles from N-arylethylamides through intramolecular C(sp3)-H functionalization under metal-free conditions is described. The method is tolerable to a wide range of substrates having a variety of functional groups with moderate to good yields of the products.

Copper-catalyzed oxidative cyclization of chalcone and benzylic amine leading to 2,5-diaryl oxazoles via carbon-carbon double bond cleavage

A copper-catalyzed oxidative cyclization of chalcone with benzylic amine is achieved, providing 2,5-diaryl oxazoles in moderate to good yields. The procedure employs O2 as a clean oxidant and involves an oxidative cleavage of the CC bond as the key step.

Iodine(III)-promoted synthesis of oxazoles through oxidative cyclization of N -styrylbenzamides

The hypervalent iodine reagent PhI(OTf)2, generated in situ, has been successfully utilized in an intramolecular oxidative cyclization of N-styrylbenzamides. In remarkably short reaction times, the desired 2,5-disubstituted oxazoles were isolated in high yields in this metal-free oxidative C-O bond-forming reaction. Georg Thieme Verlag Stuttgart, New York.