324-59-4Relevant academic research and scientific papers
Targeting Several Biologically Reported Targets of Glioblastoma Multiforme by Assaying 2D and 3D Cultured Cells
Cornu, David,Correa-Basurto, José,Fragoso-Vazquez, Manuel Jonathan,Gómez-Vidal, José Antonio,García-Vazquez, Juan Benjamin,Méndez-Luna, David,Marhuenda, Emilie,Norbert, Bakalara,Rosales-Hernández, Martha Cecilia,Sixto-López, Yudibeth,Zacarías-Lara, Oscar
, (2021/03/23)
Glioblastoma multiforme (GBM) is account for 70% of all primary malignancies of the central nervous system. The median survival of human patients after treatment is around 15?months. There are several biological targets which have been reported that can b
Nickel-Catalyzed Cyanation of Aryl Halides and Hydrocyanation of Alkynes via C-CN Bond Cleavage and Cyano Transfer
Chen, Hui,Sun, Shuhao,Liu, Yahu A.,Liao, Xuebin
, p. 1397 - 1405 (2020/02/04)
We report nickel-catalyzed cyanation and hydrocyanation methods to prepare aryl nitriles and vinyl nitriles from aryl halides and alkynes, respectively. Using inexpensive and nontoxic 4-cyanopyridine N-oxide as the cyano shuttle, the methods provide an efficient approach to prepare aryl cyanides and vinyl nitriles under mild and operationally simple reaction conditions with a broad range of functional group tolerances. In hydrocyanation of alkynes, the method demonstrated good regioselectivity, producing predominantly E- or Z-alkenyl nitriles in a controlled manner and exclusively Markovnikov vinyl nitriles when internal diaryl alkynes and terminal alkynes were applied as the substrates, respectively. The preliminary mechanistic investigation indicated that the C-CN bond cleavage process is promoted by oxidative addition to the nickel(I) complex in the cyanation of aryl halides, and further studies via a series of deuterium exchange experiments indicated that water serves as the hydrogen source for the hydrocyanation of alkynes.
Synthesis and photophysical properties of new reactive fluorophenanthrenes
Albalawi, Marzough A.,Aloui, Faouzi,Elsayed, Nadia H.,Hajri, Amira K.
, p. 315 - 327 (2020/12/07)
A series of six new suitably functionalized fluorophenanthrene derivatives were synthesized through a simple procedure, making use of inexpensive starting materials under mild conditions. The target phenanthrenes were characterized by 1H and 13C NMR and F
