3240-16-2

Usage

Uses

Used in Organic Synthesis:
(E)-1-(2-Pyridyl)ethanone O-acetyl oxime is used as a reagent in organic synthesis for the creation of various natural and synthetic organic compounds. Its unique structure and reactivity make it a valuable component in the development of new molecules with potential applications in various fields.
Used in Coordination Chemistry:
In coordination chemistry, (E)-1-(2-Pyridyl)ethanone O-acetyl oxime is employed as a chelating agent. Its ability to form stable complexes with metal ions is crucial for the study and development of new coordination compounds with potential applications in areas such as catalysis, materials science, and medicinal chemistry.
Used in Pharmaceutical Applications:
(E)-1-(2-Pyridyl)ethanone O-acetyl oxime has been studied for its potential biological activities and pharmaceutical applications. Its unique chemical properties and interactions with biological systems make it a promising candidate for the development of new drugs and therapeutic agents.
Used in Research and Development:
(E)-1-(2-Pyridyl)ethanone O-acetyl oxime is also utilized in research and development settings, where it serves as a key intermediate or building block in the synthesis of more complex molecules. Its versatility and reactivity contribute to the advancement of scientific knowledge and the discovery of novel applications in various industries.

Upstream product

• 1758-54-9 1-pyridin-2-yl-ethanone oxime 
• 75-36-5 acetyl chloride 
• 1122-62-9 2-acetylpyridine 
• 108-24-7 acetic anhydride 

Relevant academic research and scientific papers

Copper-Catalyzed Annulation of Oxime Acetates with α-Amino Acid Ester Derivatives: Synthesis of 3-Sulfonamido/Imino 4-Pyrrolin-2-ones

A copper-catalyzed annulation of oxime acetates and α-amino acid ester derivatives for the easy preparation of 4-pyrrolin-2-ones bearing a 3-amino group has been developed. This process features the oxidation of amines with oxime esters as the internal oxidant to produce the active 1,3-dinucleophilic and 1,2-dielectrophilic species concurrently. The subsequent nucleophilic cyclization realizes the efficient construction of 4-pyrrolin-2-one derivatives.

Site-Selective Esterifications of Polyol β-Hydroxyamides and Applications to Serine-Selective Glycopeptide Modifications

The site-selective acylations of β-hydroxyamides in the presence of other hydroxyl groups are described. Central to the success of this modification is the metal-template-driven acylation using pyridine ketoxime esters as acylating reagents in combination

Copper-catalyzed synthesis of thiazol-2-yl ethers from oxime acetates and xanthates under redox-neutral conditions

A novel copper-catalyzed annulation of oxime acetates and xanthates for the synthesis of thiazol-2-yl ethers with remarkable regioselectivity has been developed. Various oxime acetates, whether derived from aryl ketones or alkyl ketones, or natural product cores are suitable for this conversion. Unique dihydrothiazoles were also obtained when both reaction sites were methine. Mechanistic studies indicated that imino copper(iii) intermediates were involved. In addition, this protocol proceeded under redox-neutral conditions and did not require additives or ligands.

Synthesis of enaminones via copper-catalyzed decarboxylative coupling reaction under redox-neutral conditions

A novel copper-catalyzed C(sp3)-H oxidative functionalization of aromatic oxime acetates with α-oxocarboxylic acids was reported. This process involved N-O/C-C bond cleavages and C-C bond formations to furnish substituted enaminones under redox-neutral conditions. The oxime acetates served as both reactants and internal oxidants. Furthermore, this transformation also features good functional group tolerance and needs no ligands or additional bases.

Ruthenium-catalyzed cyclization of ketoxime acetates with DMF for synthesis of symmetrical pyridines

A novel ruthenium-catalyzed cyclization of ketoxime carboxylates with N,N-dimethylformamide (DMF) for the synthesis of tetrasubstituted symmetrical pyridines has been developed. A methyl carbon on DMF performed as a source of a one carbon synthon. And NaHSO3 plays a role in the reaction.