324034-56-2 Usage
Description
(S)-α-tert-Butyl-1-naphthylmethylamine is a chemical compound with the molecular formula C17H21N. It is a chiral amine that consists of a tert-butyl group and a 1-naphthylmethyl moiety. (S)-α-tert-Butyl-1-naphthylmethylamine is known for its unique structural properties and versatile applications in various fields.
Uses
Used in Organic Synthesis:
(S)-α-tert-Butyl-1-naphthylmethylamine is used as a chiral auxiliary in organic synthesis for the preparation of various biologically active molecules. Its unique structure and chiral properties make it a valuable tool in creating complex organic compounds with specific stereochemistry.
Used in Asymmetric Catalysis:
In the field of asymmetric catalysis, (S)-α-tert-Butyl-1-naphthylmethylamine is used as a ligand, particularly in the formation of chiral metal complexes. Its presence can significantly enhance the selectivity and efficiency of catalytic reactions, leading to the production of enantiomerically pure compounds.
Used in Pharmaceutical Industry:
(S)-α-tert-Butyl-1-naphthylmethylamine is a valuable building block for the preparation of chiral pharmaceuticals. Its incorporation into drug molecules can improve their efficacy, selectivity, and reduce potential side effects by targeting specific biological receptors.
Used in Agrochemical Industry:
Similarly, in the agrochemical industry, (S)-α-tert-Butyl-1-naphthylmethylamine is utilized for the synthesis of chiral agrochemicals. These chiral compounds can exhibit improved performance, such as higher activity against target pests or pathogens, and reduced environmental impact.
Used in Materials Science:
(S)-α-tert-Butyl-1-naphthylmethylamine also has potential applications in the field of materials science. It can be used for the production of optically active polymers and functional materials, which can find use in various technological applications, such as sensors, displays, and advanced materials with specific properties.
Check Digit Verification of cas no
The CAS Registry Mumber 324034-56-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,2,4,0,3 and 4 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 324034-56:
(8*3)+(7*2)+(6*4)+(5*0)+(4*3)+(3*4)+(2*5)+(1*6)=102
102 % 10 = 2
So 324034-56-2 is a valid CAS Registry Number.
324034-56-2Relevant articles and documents
Synthesis of 3,3-disubstituted oxindoles by palladium-catalyzed asymmetric intramolecular α-arylation of amides: Reaction development and mechanistic studies
Katayev, Dmitry,Jia, Yi-Xia,Sharma, Akhilesh K.,Banerjee, Dipshikha,Besnard, Celine,Sunoj, Raghavan B.,Kuendig, E. Peter
, p. 11916 - 11927 (2013/09/23)
Palladium complexes incorporating chiral N-heterocyclic carbene (NHC) ligands catalyze the asymmetric intramolecular α-arylation of amides producing 3,3-disubstituted oxindoles. Comprehensive DFT studies have been performed to gain insight into the mechanism of this transformation. Oxidative addition is shown to be rate-determining and reductive elimination to be enantioselectivity-determining. The synthesis of seven new NHC ligands is detailed and their performance is compared. One of them, L8, containing a tBu and a 1-naphthyl group at the stereogenic centre, proved superior and was very efficient in the asymmetric synthesis of fifteen new spiro-oxindoles and three azaspiro-oxindoles often in high yields (up to 99 %) and enantioselectivities (up to 97 % ee; ee=enantiomeric excess). Three palladacycle intermediates resulting from the oxidative addition of [Pd(NHC)] into the aryl halide bond were isolated and structurally characterized (X-ray). Using these intermediates as catalysts showed alkene additives to play an important role in increasing turnover number and frequency. Copyright
