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2-(((3-(1H-benzo[d]imidazol-2-yl)phenyl)imino)-methyl)phenol is a Schiff base ligand derived from the condensation of a benzimidazole-containing aniline derivative and salicylaldehyde. 2-(((3-(1H-benzo[d]imidazol-2-yl)phenyl)imino)-methyl)phenol has been studied for its potential pharmacological activities, particularly in forming metal complexes (e.g., with lanthanides or copper) that exhibit enhanced biological properties, including cytotoxicity against cancer cell lines, antiparasitic effects, and antibacterial activity. The ligand and its complexes interact with biological targets such as DNA and microbial proteins, suggesting a mechanism involving groove binding and receptor-specific interactions. Its antimicrobial and anticancer potential highlights its relevance in medicinal chemistry research.

324061-24-7

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324061-24-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 324061-24-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,2,4,0,6 and 1 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 324061-24:
(8*3)+(7*2)+(6*4)+(5*0)+(4*6)+(3*1)+(2*2)+(1*4)=97
97 % 10 = 7
So 324061-24-7 is a valid CAS Registry Number.

324061-24-7Relevant articles and documents

In vitro evaluation of the potential pharmacological activity and molecular targets of new benzimidazole-based schiff base metal complexes

Aragón-Muriel, Alberto,Liscano, Yamil,Morales-Morales, David,O?ate-Garzón, Jose,Polo-Cerón, Dorian,Ramírez-Apan, María Teresa,Robledo, Sara M.,Upegui, Yulieth

, (2021)

Metal-based drugs, including lanthanide complexes, have been extremely effective in clinical treatments against various diseases and have raised major interest in recent decades. Hence, in this work, a series of lanthanum (III) and cerium (III) complexes, including Schiff base ligands derived from (1H-benzimidazol-2-yl)aniline, salicylaldehyde, and 2,4-dihydroxybenzaldehyde were synthesized and characterized using different spectroscopic methods. Besides their cytotoxic activities, they were examined in human U-937 cells, primate kidney non-cancerous COS-7, and six other, different human tumor cell lines: U251, PC-3, K562, HCT-15, MCF-7, and SK-LU-1. In addition, the synthesized compounds were screened for in vitro antiparasitic activity against Leishmania braziliensis, Plasmodium falciparum, and Trypanosoma cruzi. Additionally, antibacterial activities were examined against two Gram-positive strains (S. aureus ATCC 25923, L. monocytogenes ATCC 19115) and two Gram-negative strains (E. coli ATCC 25922, P. aeruginosa ATCC 27583) using the microdilution method. The lanthanide complexes generally exhibited increased biological activity compared with the free Schiff base ligands. Interactions between the tested compounds and model membranes were examined using differential scanning calorimetry (DSC), and interactions with calf thymus DNA (CT-DNA) were investigated by ultraviolet (UV) absorption. Molecular docking studies were performed using leishmanin (1LML), cruzain (4PI3), P. falciparum alpha-tubulin (GenBank sequence CAA34101 [453 aa]), and S. aureus penicillin-binding protein 2a (PBP2A; 5M18) as the protein receptors. The results lead to the conclusion that the synthesized compounds exhibited a notable effect on model membranes imitating mammalian and bacterial membranes and rolled along DNA strands through groove interactions. Interactions between the compounds and studied receptors depended primarily on ligand structures in the molecular docking study.

Synthesis, Characterization and Antimicrobial Activities of Copper(II) Complexes of Schiff Base Ligand 2-[(3′-N-salicylidinephenyl)benzimidazole]

Roopashree,Gayathri

, p. 1979 - 1984 (2019)

CuX2·6H2O (X = Cl–, Br– or ClO4–) reacted with a Schiff base ligand 2-[(3′-N-salicylidinephenyl)benzimidazole] in 1:2 mole ratio in methanol to yield brown colored complexes of types [CuCl2L]2, [CuBr1.5L1.5]2Br and [Cu(OCl

Efficient and facile synthesis of benzimidazole induced schiff bases and their potent antibacterial activity and computational study

GURAV, SHAILESH S.,WAGHMODE, KRISHNAKANT T.,NIKAM, BANDOBA T.

, p. 1261 - 1266 (2021/06/09)

Synthesized benzimidazole induced Schiff base analogues were characterized by mass, 13C NMR, 1H NMR and UV-visible spectroscopy. To get more information about binding mechanism, molecular docking studies were carried out and the obtained results concluded

Syntheses, characterizations, and antimicrobial activities of binuclear ruthenium(III) complexes containing 2-substituted benzimidazole derivatives

Roopashree,Gayathri,Gopi,Devaraju

, p. 4023 - 4040 (2013/02/25)

Binuclear ruthenium(III) complexes [RuX3L]2· nH2O (X=Cl, L=L1, L2, L3; n=1, L4 and L5, X=Br; L=L3), [RuX3L 1.5]2·nH2O (X=Br, L=L1; n=0, L4; n=6 and L5; n=10), and [RuX3L 2]2 (X=Br, L=L2) have been isolated by treatment of hydrated RuX3 (X=Cl/Br) in acetone with 2-(2′-aminophenylbenzimidazole) (L1), 2-(3′- aminophenylbenzimidazole) (L2), 2-[(3′-N-salicylidinephenyl) benzimidazole] (L3), 2-(3′-pyridylbenzimidazole) (L 4), and 2-(4′-pyridylbenzimidazole) (L5) in acetone. The complexes were characterized by elemental analysis, conductivity and magnetic susceptibility measurements, IR, electronic, EPR, and mass spectral studies. The complexes were dimeric; based on analytical and spectral studies, an octahedral geometry was proposed for the complexes. The synthesized complexes were screened against Gram-positive and Gram-negative bacteria and fungi.

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