324074-94-4Relevant academic research and scientific papers
New method of 4,5-disubstituted 1,2,4-triazolo-3-thiones synthesis
Milczarska, Barbara,Foks, Henryk
, p. 197 - 204 (2007/10/03)
A universal method of 4,5-disubstituted S-triazolo-3-thiones synthesis from methyl esters of arylothiocarbazoic acids and some primary amines is presented. Copyright Taylor & Francis Inc.
Synthesis of new 5-substituted 1,2,4-triazole-3-thione derivatives
Foks, Henryk,Czarnocka-Janowicz, Anna,Rudnicka, Waleria,Trzeciak, Henryk
, p. 67 - 81 (2007/10/03)
In the present paper we describe the preparation of series of new derivatives of 1,2,4-triazole-3-thiol. As starting materials methyl 3-acyldithiocarbazates were used, which on reaction with amines gave the corresponding 4,5-disubstituted 1,2,4-triazole-3-thiol derivatives (3). Into the 4-position of the 1,2,4-triazole-3-thiol system a β-hydroxyetlhyl substituent was introduced (compounds 4). These compounds were alkylated with methyl iodide to from 6, with N-substituted amides of chloroacetic acid (products 7 and 8), and aminomethylated with formation of Mannich bases (10). Some of the thiols 4 were desulfurized to 9. The new compounds were tested for their circulatory activity, but found not pharmacologically active.
