7449-45-8

Upstream product

• 5397-03-5 hydrazinecarbodithioic acid methyl ester 
• 98-88-4 benzoyl chloride 
• 75-15-0 carbon disulfide 
• 613-94-5 benzoic acid hydrazide 
• 74-88-4 methyl iodide 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 1925-71-9 2-methylmercapto-5-phenyl-1,3,4-thiadiazole 
• 22706-11-2 4-amino-3-phenyl-1H-1,2,4-triazole-5(4H)-thione 
• 23288-88-2 2-(methylthio)-5-phenyl-1,3,4-oxadiazole 
• 324074-94-4 4-(2-morpholin-4-yl-ethyl)-5-phenyl-4H-[1,2,4]triazole-3-thiol 
• 849587-33-3 4-(3-ethoxy-propyl)-5-phenyl-4H-[1,2,4]triazole-3-thiol 
• 664308-50-3 3-(3-mercapto-5-phenyl-[1,2,4]triazol-4-yl)-propan-1-ol 
• 3357-42-4 3-phenyl-1,2,4-triazole 
• 38345-23-2 4-amino-3-phenyl-1,2,4-triazole 
• 39573-67-6 4-amino-3-methylthio-5-phenyl-1,2,4-triazole 
• 114402-22-1 4H-4-amino-5-carboxymethylsulfanyl-3-phenyl-1,2,4-triazole 
• 169304-24-9 ethyl 2-[(4-amino-5-phenyl-4H-1,2,4-triazol-3-yl)thio]acetate 
• 79074-65-0 3,6-diphenyl<1,2,4>triazolo<3,4-b><1,3,4>thiadiazine 
• 97035-43-3 5,5'-diphenyl-3,3'-disulfanediyl-bis-[1,2,4]triazol-4-ylamine 

Relevant academic research and scientific papers

New method of 4,5-disubstituted 1,2,4-triazolo-3-thiones synthesis

A universal method of 4,5-disubstituted S-triazolo-3-thiones synthesis from methyl esters of arylothiocarbazoic acids and some primary amines is presented. Copyright Taylor & Francis Inc.

Synthesis of new 5-substituted 1,2,4-triazole-3-thione derivatives

In the present paper we describe the preparation of series of new derivatives of 1,2,4-triazole-3-thiol. As starting materials methyl 3-acyldithiocarbazates were used, which on reaction with amines gave the corresponding 4,5-disubstituted 1,2,4-triazole-3-thiol derivatives (3). Into the 4-position of the 1,2,4-triazole-3-thiol system a β-hydroxyetlhyl substituent was introduced (compounds 4). These compounds were alkylated with methyl iodide to from 6, with N-substituted amides of chloroacetic acid (products 7 and 8), and aminomethylated with formation of Mannich bases (10). Some of the thiols 4 were desulfurized to 9. The new compounds were tested for their circulatory activity, but found not pharmacologically active.