324075-34-5

Upstream product

• 75-15-0 carbon disulfide 
• 536-40-3 4-chlorobenzoic acid hydrazide 
• 77-78-1 dimethyl sulfate 
• 74-88-4 methyl iodide 

Downstream Products

• 664308-55-8 1-[3-(4-chloro-phenyl)-5-mercapto-[1,2,4]triazol-4-yl]-propan-2-ol 
• 849587-44-6 5-(4-chloro-phenyl)-4-(3-ethoxy-propyl)-4H-[1,2,4]triazole-3-thiol 
• 849587-42-4 4-[3-(4-chloro-phenyl)-5-mercapto-[1,2,4]triazol-4-yl]-butan-1-ol 
• 849587-43-5 3-[3-(4-chloro-phenyl)-5-mercapto-[1,2,4]triazol-4-yl]-propane-1,2-diol 
• 849587-45-7 5-(4-chloro-phenyl)-4-(2-piperidin-1-yl-ethyl)-4H-[1,2,4]triazole-3-thiol 

Relevant academic research and scientific papers

New method of 4,5-disubstituted 1,2,4-triazolo-3-thiones synthesis

A universal method of 4,5-disubstituted S-triazolo-3-thiones synthesis from methyl esters of arylothiocarbazoic acids and some primary amines is presented. Copyright Taylor & Francis Inc.

Synthesis of new 5-substituted 1,2,4-triazole-3-thione derivatives

In the present paper we describe the preparation of series of new derivatives of 1,2,4-triazole-3-thiol. As starting materials methyl 3-acyldithiocarbazates were used, which on reaction with amines gave the corresponding 4,5-disubstituted 1,2,4-triazole-3-thiol derivatives (3). Into the 4-position of the 1,2,4-triazole-3-thiol system a β-hydroxyetlhyl substituent was introduced (compounds 4). These compounds were alkylated with methyl iodide to from 6, with N-substituted amides of chloroacetic acid (products 7 and 8), and aminomethylated with formation of Mannich bases (10). Some of the thiols 4 were desulfurized to 9. The new compounds were tested for their circulatory activity, but found not pharmacologically active.