324075-71-0

Upstream product

• 455-19-6 4-Trifluoromethylbenzaldehyde 
• 324075-41-4 6-methoxy-1-methyl-4-(trifluoromethyl)isoquinoline 
• 324075-39-0 4,6-dimethoxy-1-methyl-4-trifluoromethyl-3,4-dihydroisoquinoline 
• 324075-46-9 N-[2-methoxy-2-(3-methoxyphenyl)-2-(trifluoromethyl)ethyl]-4-(trifluoromethyl)cinnamic amide 
• 324075-36-7 N-[2-methoxy-2-(3-methoxyphenyl)-2-(trifluoromethyl)ethyl]acetamide 
• 324075-37-8 3,3,3-trifluoro-2-methoxy-2-(3-methoxyphenyl)propylamine 
• 324075-44-7 3,3,3-trifluoro-2-methoxy-2-(3-methoxyphenyl)propionitrile 
• 105919-36-6 trans-4-(trifluoromethyl)cinnamoyl chloride 
• 30724-22-2 2,2,2-trifluoro-1-(3-methoxyphenyl)ethanone 

Relevant academic research and scientific papers

Synthesis of 4-(trifluoromethyl)isoquinolines. Influence of trifluoromethyl group on the Pictet-Gams ring closure reaction

Treatment of N-acyl-2-methoxy-2-(trifluoromethyl)arylethylamines under Pictet-Gams conditions afforded 4-methoxy-4-trifluoromethyl-3,4-dihydroisoquinolines which were aromatised by base catalysed methanol elimination. Earlier we described the synthesis of 2-oxazolines by conducting the Pictet-Gams sequence with N-acyl-2-hydroxy-2-(trifluoromethyl)arylethylamines. The operation of these two pathways is explained by the influence of the trifluoromethyl group.