324075-46-9Relevant academic research and scientific papers
Synthesis of 4-(trifluoromethyl)isoquinolines. Influence of trifluoromethyl group on the Pictet-Gams ring closure reaction
Poszávácz, László,Simig, Gyula
, p. 8573 - 8580 (2007/10/03)
Treatment of N-acyl-2-methoxy-2-(trifluoromethyl)arylethylamines under Pictet-Gams conditions afforded 4-methoxy-4-trifluoromethyl-3,4-dihydroisoquinolines which were aromatised by base catalysed methanol elimination. Earlier we described the synthesis of 2-oxazolines by conducting the Pictet-Gams sequence with N-acyl-2-hydroxy-2-(trifluoromethyl)arylethylamines. The operation of these two pathways is explained by the influence of the trifluoromethyl group.
