32416-92-5Relevant academic research and scientific papers
Development of N-benzamidothioureas as a new generation of thiourea-based receptors for anion recognition and sensing
Nie, Li,Li, Zhao,Han, Jie,Zhang, Xuan,Yang, Rui,Liu, Wen-Xia,Wu, Fang-Ying,Xie, Jian-Wei,Zhao, Yu-Fen,Jiang, Yun-Bao
, p. 6449 - 6454 (2004)
A series of neutral N-(substituted-benzamido)-N′-phenylthioureas (substituent = p-OC2H5, p-CH3, m-CH 3, H, p-Cl, p-Br, m-Cl, and p-NO2) were designed as anion receptors, in which the thiourea binding site was attached to the benzamido moiety via an N-N bond. The absorption spectra of these N-benzamidothioureas in acetonitrile peaked at ca. 270 nm were found to show unprecedented red shifts by 7 373 to 14 325 cm-1 in the presence of anions such as AcO-, F-, and H2PO4-. Under the same conditions, the classic neutral thiourea receptors, N-(substituted-phenyl)-N′-phenylthioureas, showed absorption spectral shifts in most cases of less than 800 cm-1 with one exception of 6501 cm-1. Control experiments, effects of protic solvent, and 1H NMR titration confirmed the formation of hydrogen-bonding complexes between the new N-benzamidothiourea receptors and anions. The binding constants with AcO-, for example, are at 10 5-107 mol-1 L order of magnitude, which are 13 to 590 times those of the corresponding classic N-phenylthioureas in the same solvent. It was found that, whereas the absorption of the N-benzamidothiourea receptors showed essentially no dependence on the substituent, the substantially red-shifted new absorption band of the N-benzamidothiourea-anion binding complex was sensitively subject to the substituent. A linear relationship was found between the absorption energies of the N-benzamidothiourea-acetate binding complexes and the Hammett constants of the substituents with a negative slope of -0.34 eV. This led to the assignment that the substantially red-shifted absorption band was the ground-state intramolecular charge-transfer absorption with the substituent locating in the electron acceptor moiety. It was concluded that anion binding to the thiourea moiety of the N-benzamidothiourea receptors switched on their ground-state charge transfer. An anion-binding induced structural change was suggested to occur around the N-N bond in N-benzamidothioureas, which resulted in a substantially increased electron donating ability of the electron donor in the receptor molecules. As a consequence, the ground-state charge transfer takes place in the N-benzamidothiourea-anion binding complexes, leading to unprecedented red shifts in the absorption spectra and substantially enhanced anion binding affinities than those of the corresponding N-phenylthiourea receptors. N-Benzamido- N′-phenylthioureas represent a new generation of neutral thiourea-based anion receptors that show substantially improved anion binding performance important for anion sensing and recognition.
