32418-99-8

Basic information

• Product Name: 3-AMINO-TETRAHYDRO-THIOPHENE-3-CARBOXYLIC ACID
• Synonyms: 3-AMINO-TETRAHYDRO-THIOPHENE-3-CARBOXYLIC ACID;RARECHEM AM UF SCH6;3-Thiophenecarboxylicacid,3-aminotetrahydro-(8CI,9CI);3-aminothiolane-3-carboxylic acid
• CAS NO: 32418-99-8
• Molecular Formula: C5H9NO2S
• Molecular Weight: 147.2
• Product Categories: CARBOXYLICACID
• Mol File: 32418-99-8.mol

Chemical Properties

• Boiling Point: 325.682 °C at 760 mmHg
• Flash Point: 150.767 °C
• Appearance: /
• Density: 1.383g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.595
• CAS DataBase Reference: 3-AMINO-TETRAHYDRO-THIOPHENE-3-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AMINO-TETRAHYDRO-THIOPHENE-3-CARBOXYLIC ACID(32418-99-8)
• EPA Substance Registry System: 3-AMINO-TETRAHYDRO-THIOPHENE-3-CARBOXYLIC ACID(32418-99-8)

Safety Data

• Hazardous Substances Data: 32418-99-8(Hazardous Substances Data)

Usage

Uses

Used in Synthetic Organic Chemistry:
3-Amino-tetrahydro-thiophene-3-carboxylic acid is used as a building block for the synthesis of various organic compounds. Its unique structure allows it to be a valuable component in the creation of complex molecules, which can be utilized in a wide range of applications, from pharmaceuticals to materials science.
Used in Pharmaceutical Development:
Due to its structural elements, 3-Amino-tetrahydro-thiophene-3-carboxylic acid may be employed as a key intermediate in the development of new pharmaceutical compounds. Its potential role in drug synthesis could lead to the discovery of novel therapeutic agents with improved efficacy and safety profiles.
Used in Materials Science:
3-Amino-tetrahydro-thiophene-3-carboxylic acid's properties may also make it suitable for use in the development of new materials with specific characteristics. Its incorporation into material compositions could result in advancements in areas such as electronics, coatings, and adhesives, where novel materials with tailored properties are constantly in demand.

InChI:InChI=1/C5H9NO2S/c6-5(4(7)8)1-2-9-3-5/h1-3,6H2,(H,7,8)

Upstream product

• 212710-51-5 7-thia-1,3-diazaspiro[4.4]nonane-2,4-dione 

Downstream Products

• 778602-62-3 3-(benzyloxycarbonylamino)tetrahydrothiophene-3-carboxylic acid 
• 1429861-98-2 (R)-3-(benzyloxycarbonylamino)tetrahydrothiophene-3-carboxylic acid 
• 1429861-96-0 (3S)-(benzyloxycarbonylamino)tertrahydrothiophene-3-carboxylic acid (1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl ester 
• 1429861-97-1 (S)-3-(benzyloxycarbonylamino)tetrahydrothiophene-3-carboxylic acid 
• 108329-86-8 3-((tert-butoxycarbonyl)amino)tetrahydrothiophene-3-carboxylic acid 
• 742051-73-6 methyl 3-aminotetrahydrothiophene-3-carboxylate 

Relevant articles and documents

Synthesis of sterically hindered N-acylated amino acids from N-carboxyanhydrides

Sterically hindered N-acyl, gem-disubstituted amino acids are easily prepared via the addition of organometallic reagents to N-carboxyanhydrides (NCA). The process tolerates a wide variety of functional groups and allows the synthesis of amide products not readily accessible by traditional acylation chemistry. The existence of an isocyanate intermediate was established by in situ IR spectroscopy.

Synthesis of both enantiomers of cyclic methionine analogue: (R)- and (S)-3-aminotetrahydrothiophene-3-carboxylic acids

A method of synthesizing an optically active cyclic methionine analogue, 3-aminotetrahydrothiophene-3-carboxylic acid (At5c), is described. A Bucherer-Bergs reaction of 4,5-dihydro-3(2H)-thiophenone and the subsequent alkaline hydrolysis of a h

A new series of cyclic amino acids as inhibitors of S-adenosyl L- methionine synthetase

Optically active 3-amino-3-(tetrahydrofuranyl) carboxylic acid, 3- amino-3-(tetrahydrothienyl) carboxylic acid and their corresponding six membered ring analogues have been synthesised and examined as potential inhibitors of the enzyme S-adenosylmethionine (AdoMet) synthetase. The kinetic behaviour of these compounds was studied using recombinant rat liver AdoMet synthetase (α-isoform) fractionated from E. coli transformed with the plasmid pSSRL-T7N. All the compounds tested were competitive inhibitors of the enzyme with respect to L-methionine.