742051-73-6Relevant articles and documents
A new series of cyclic amino acids as inhibitors of S-adenosyl L- methionine synthetase
Lavrador, Karine,Guillerm, Danielle,Guillerm, Georges
, p. 1629 - 1634 (1998)
Optically active 3-amino-3-(tetrahydrofuranyl) carboxylic acid, 3- amino-3-(tetrahydrothienyl) carboxylic acid and their corresponding six membered ring analogues have been synthesised and examined as potential inhibitors of the enzyme S-adenosylmethionine (AdoMet) synthetase. The kinetic behaviour of these compounds was studied using recombinant rat liver AdoMet synthetase (α-isoform) fractionated from E. coli transformed with the plasmid pSSRL-T7N. All the compounds tested were competitive inhibitors of the enzyme with respect to L-methionine.