32428-71-0

Basic information

• Product Name: 2-ETHYL-6-METHYL-2-CHLOROACETANILIDE
• Synonyms: 2-CHLORO-N-(2-ETHYL-6-METHYLPHENYL)ACETAMIDE;2-CHLORO-(N-2-METHYL-6-ETHYL PHENYL)ACETAMIDE;2-chloro-N-(2-ethyl-6-methyl-phenyl)ethanamide;CMEPA;N-(Chloroacetyl)-2-ethyl-6-methylaniline;CGA 13656
• CAS NO: 32428-71-0
• Molecular Formula: C₁₁H₁₄ClNO
• Molecular Weight: 211.68796
• Mol File: 32428-71-0.mol
• Article Data: 2

Chemical Properties

• Melting Point: 120-121 °C(Solv: ethanol, 50% (64-17-5))
• Boiling Point: 343.1oC at 760 mmHg
• Flash Point: 161.3oC
• Appearance: /
• Density: 1.156g/cm3
• Vapor Pressure: 7.18E-05mmHg at 25°C
• Refractive Index: 1.566
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: Chloroform (Slightly), Methanol (Slightly, Heated)
• PKA: 12.91±0.70(Predicted)
• CAS DataBase Reference: 2-ETHYL-6-METHYL-2-CHLOROACETANILIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-ETHYL-6-METHYL-2-CHLOROACETANILIDE(32428-71-0)
• EPA Substance Registry System: 2-ETHYL-6-METHYL-2-CHLOROACETANILIDE(32428-71-0)

Safety Data

• Hazardous Substances Data: 32428-71-0(Hazardous Substances Data)

Usage

General Description

2-Ethyl-6-methyl-2-chloroacetanilide, also known as ethamydil or acetamide, is a chemical compound primarily used as a precursor in the synthesis of other pharmaceuticals and agrochemicals. It is a chloroacetanilide herbicide, which means it is widely employed in agriculture to control grasses and broad-leaved weeds. This chemical acts by inhibiting cell division and is absorbed by the roots of the targeted plants, effectively disrupting their growth. In addition to its agricultural applications, 2-ethyl-6-methyl-2-chloroacetanilide is also used in the synthesis of pharmaceuticals and other organic compounds due to its ability to act as a stabilizer or intermediate in chemical reactions. However, it is important to handle this compound with caution as it can be harmful if it comes into contact with the skin or is ingested.

InChI:InChI=1/C11H14ClNO/c1-3-9-6-4-5-8(2)11(9)13-10(14)7-12/h4-6H,3,7H2,1-2H3,(H,13,14)

Upstream product

• 24549-06-2 6-ethyl-o-toluidine 
• 79-04-9 chloroacetyl chloride 

Downstream Products

• 76213-34-8 2-amino-2'-ethyl-6'-methylacetanilide 
• 84243-44-7 1-[(2-ethyl-6-methylphenyl)carbamoylmethyl]-2-methyl-2-imidazoline 
• 133035-87-7 N-(2-Ethyl-6-methyl-phenyl)-2-(4-hydroxy-6-methoxy-2,2-dimethyl-chroman-7-yloxy)-acetamide 
• 133035-82-2 N-(2-Ethyl-6-methyl-phenyl)-2-(4-hydroxy-7-methoxy-2,2-dimethyl-chroman-6-yloxy)-acetamide 
• 133035-76-4 N-(2-Ethyl-6-methyl-phenyl)-2-(4-hydroxy-2,2,8-trimethyl-chroman-7-yloxy)-acetamide 
• 133035-70-8 N-(2-Ethyl-6-methyl-phenyl)-2-(4-hydroxy-2,2,5-trimethyl-chroman-7-yloxy)-acetamide 
• 133035-64-0 N-(2-Ethyl-6-methyl-phenyl)-2-(4-hydroxy-2,2-dimethyl-chroman-7-yloxy)-acetamide 
• 133036-08-5 N-(2-Ethyl-6-methyl-phenyl)-2-(7-methoxy-2,2-dimethyl-2H-chromen-6-yloxy)-acetamide 
• 133036-13-2 N-(2-Ethyl-6-methyl-phenyl)-2-(6-methoxy-2,2-dimethyl-2H-chromen-7-yloxy)-acetamide 
• 133036-02-9 N-(2-Ethyl-6-methyl-phenyl)-2-(2,2,8-trimethyl-2H-chromen-7-yloxy)-acetamide 
• 133035-96-8 N-(2-Ethyl-6-methyl-phenyl)-2-(2,2,5-trimethyl-2H-chromen-7-yloxy)-acetamide 
• 133035-90-2 2-(2,2-Dimethyl-2H-chromen-7-yloxy)-N-(2-ethyl-6-methyl-phenyl)-acetamide 
• 34256-82-1 Acetochlor 
• 85232-13-9 2-Chloro-N-[2-(2-ethoxy-ethoxy)-ethoxymethyl]-N-(2-ethyl-6-methyl-phenyl)-acetamide 

Relevant articles and documents

Design, synthesis, antibacterial and quorum quenching studies of 1,2,5-trisubstituted 1,2,4-triazoles

Abstract: In view of discovering novel bioactive molecules, 1-phenyl-1H-2-(1-aryl-5-methyl-1H-1,2,3-triazol-4-yl)-3-(N-aryl-carbamoylmethylthio)-1,2,4-triazoles (8a–n) were designed and synthesized in good yield. Preliminary antibacterial activity was tested against Chromobacterium violaceum and Xanthomonas campestris pv. Campestris (Xcc). Out of 14 derivatives, compound 8g selectively possessed antibacterial activity against C. violaceum. Further derivatives that possessed an electron-withdrawing group and halogen atoms in N-phenylacetamide moiety were moderately active against Xcc (plant pathogen). After observing the reduction of violacein production through plate assay, compounds 8a, 8c, 8h, 8i and 8m were subjected to quantification of quorum sensing inhibition. Compounds with the electron-withdrawing group in N-phenylacetamide moiety showed admirable activity with > 80% inhibition of violacein. Mainly compound 8c which was inactive against the growth of bacteria were identified as excellent QSI which could be a lead compound for further development. Graphic abstract: One of the best approaches to acquire anti-virulence strategies and new direction for the discovery of antibacterial drugs[Figure not available: see fulltext.]