32445-89-9

Usage

Uses

Used in Pharmaceutical Industry:
2-Methyl-2-[4-(trifluoromethyl)phenyl]propanoic acid is used as a key intermediate in the synthesis of triazoles and related compounds. These compounds serve as inhibitors of 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1), an enzyme that plays a crucial role in various metabolic processes. Inhibition of this enzyme has been linked to the treatment of conditions such as type 2 diabetes, obesity, and cardiovascular diseases.
Used in Chemical Synthesis:
In the chemical industry, 2-Methyl-2-[4-(trifluoromethyl)phenyl]propanoic acid can be utilized as a building block for the development of new compounds with potential applications in various fields, including materials science, agrochemistry, and pharmaceuticals. Its unique structure and reactivity make it a valuable component in the design and synthesis of novel molecules with specific properties and functions.

InChI:InChI=1/C11H11F3O2/c1-10(2,9(15)16)7-3-5-8(6-4-7)11(12,13)14/h3-6H,1-2H3,(H,15,16)

Upstream product

• 476429-18-2 methyl 2-methyl-2-(4-(trifluoromethyl)phenyl)propanoate 
• 32857-62-8 4-Trifluoromethylphenylacetic acid 
• 721-63-1 (4-trifluoromethylphenyl)acetic acid ethyl ester 
• 2338-75-2 4-(Trifluoromethyl)phenylacetonitrile 

Downstream Products

• 125847-20-3 2,3-dimethyl-2,3-bis(4-(trifluoromethyl)phenyl)butane 
• 15996-88-0 2-methyl-2-(4-(trifluoromethyl)phenyl)propanamide 
• 1368963-87-4 C₁₁H₁₄F₃N 
• 32454-17-4 2-methyl-2-(4-(trifluoromethyl)phenyl)propanal 
• 32445-99-1 4-isopropyl-1-(trifluoromethyl)benzene 
• 2252-62-2 2-(4-(trifluoromethyl)phenyl)propan-2-ol 
• 32445-90-2 2-(p-Trifluoromethylphenyl)-2-methyl-propan-1-ol 

Relevant academic research and scientific papers

HETEROCYCLIC COMPOUND, APPLICATION THEREOF, AND COMPOSITION CONTAINING SAME

A heterocyclic compound represented by formula XI, a pharmaceutically acceptable salt, a solvate, or a solvate of a pharmaceutically acceptable salt thereof, use thereof, and a composition containing the same. The compound is novel in structure and has good STAT5 inhibitory activity.

ARYL-SUBSTITUTED ACETAMIDE AND PYRROLIDIN-2-ONE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF SEIZURES

Aryl-substituted acetamide and pyrrolidin-2-one (γ-butyrolactam) derivatives have useful activity in the inhibition, prevention, or treatment of seizures. The derivatives may be useful in the treatment of epilepsy, including medically refractory epilepsy, and nerve agent poisoning.

Pd(II)-catalyzed enantioselective C-H activation/C-O bond formation: Synthesis of chiral benzofuranones

Pd(II)-catalyzed enantioselective C-H activation of phenylacetic acids followed by an intramolecular C-O bond formation afforded chiral benzofuranones. This reaction provides the first example of enantioselecctive C-H functionalizations through Pd(II)/Pd(IV) redox catalysis.

NAPHTHALENONE COMPOUNDS EXHIBITING PROLYL HYDROXYLASE INHIBITORY ACTIVITY, COMPOSITIONS, AND USES THEREOF

Compounds of Formula (I) and Formula (II) are useful as inhibitors of HIF prolyl hydroxylases. Compounds of Formula(I) and Formula (II) have the following structures, where the definitions of the variables are provided herein.