32454-17-4

Upstream product

• 402-44-8 4-Fluorobenzotrifluoride 
• 2338-75-2 4-(Trifluoromethyl)phenylacetonitrile 
• 74-88-4 methyl iodide 
• 6651-34-9 2-methyl-1-(trimethylsilyloxy)-1-propene 
• 402-43-7 p-trifluoromethylphenyl bromide 
• 32445-89-9 2-methyl-2-(4-(trifluoromethyl)phenyl)propanoic acid 
• 32445-87-7 2-methyl-2-(4-(trifluoromethyl)phenyl)propanenitrile 
• 32445-90-2 2-(p-Trifluoromethylphenyl)-2-methyl-propan-1-ol 

Downstream Products

• 32445-99-1 4-isopropyl-1-(trifluoromethyl)benzene 
• 144659-79-0 5-methyl-1-(3-phenoxyphenyl)-5-<4-(trifluoromethyl)phenyl>-2-hexyne-1,4-diol 
• 64436-58-4 2-methyl-1-[4-(trifluoromethyl)phenyl]propan-1-one 
• 57132-21-5 3-p-trifluoromethylphenyl-2-butanone 

Relevant academic research and scientific papers

Br?nsted Acid-Catalyzed Intramolecular Hydroarylation of β-Benzylstyrenes

Using triphenylmethylium tetrakis(pentafluorophenyl)borate as a convenient Br?nsted acid precatalyst, β-(α,α-dimethylbenzyl)styrenes are shown to cyclize efficiently to afford a variety of new indanes that possess a benzylic quaternary center. The geminal dimethyl-containing quaternary center is proposed to be necessary to arm the substrate for cyclization through steric biasing.

DITERPENOID COMPOUNDS THAT ACT ON PROTEIN KINASE C (PKC)

This present disclosure relates to protein kinase C (PKC) modulating compounds, methods of treating a subject with cancer using the compounds, and combination treatments with a second therapeutic agent.

Intermolecular Reductive Couplings of Arylidene Malonates via Lewis Acid/Photoredox Cooperative Catalysis

A cooperative Lewis acid/photocatalytic reduction of arylidene malonates yields a versatile radical anion species. This intermediate preferentially undergoes intermolecular radical-radical coupling reactions, and not the conjugate addition-dimerization reactivity typically observed in the single-electron reduction of conjugate acceptors. Reported here is the development of this open-shell species in intermolecular radical-radical cross couplings, radical dimerizations, and transfer hydrogenations. This reactivity underscores the enabling modularity of cooperative catalysis and demonstrates the utility of stabilized enoate-derived radical anions in intermolecular bond forming reactions.

GaCl3-catalyzed skeletal rearrangement of α,α, α-trisubstituted aldehydes

(Chemical Equation Presented) GaCl3 is found to be a superior catalyst for the skeletal rearrangement of α,α,α- trisubstituted aldehydes to ketones. The rearrangement can proceed smoothly in the presence of a catalytic amount of GaCl3, and even substrates having no heteroatoms α to the carbonyl group or without steric strains can be used. Double activation of a carbonyl group by two molecules of GaCl 3 was supported on the basis of experimental data and a DFT study.

5[W(substituted aryl)alkenylene and alkynylene]-2,4-diaminopyrimidines as pesticides

5-Substituted-2,4-diaminopyrimidines, and agriculturally acceptable salts thereof, when present in insecticidally or acaricidally effective amounts, and with a suitable agricultural carrier, are useful as active ingredients in novel insecticidal and acaricidal compositions. These pyrimidines may be represented by the following formula: STR1 wherein Ar is STR2 and wherein U is an alkenylene or alkynylene moiety, and R, R1, R2, R3, R4, V, W, X, Y, Z and n are as defined herein; also disclosed and claimed are novel intermediates thereof.

6-substituted-3,5-diamino-1,2,4-triazines as insecticides

An insecticidal composition comprising, in admixture with an agriculturally acceptable carrier, an insecticidally effective amount of a 1,2,4-triazine compound of the formula STR1 wherein m is 0 to 12; n is 0 or 1; T is CH2, CH=CH, or C C; X is Si(CH3)2, C(CH3)2, CH(CH3), or O; or R is methyl, vinyl, cyclopentyl, phenyl, naphthyl, or a substituted phenyl of the formula: STR2 wherein Q, U, W, Y, Z, and R1, R2, R3, R4 are as defined herein; and methods of using the same.