32449-80-2

Usage

Uses

Used in Pharmaceutical Industry:
Glucuronic acid, γ-lactone, L(8CI) is used as an intermediate in the synthesis of iduronic acid, which is an essential component of certain glycosaminoglycans (GAGs). These GAGs are vital for various biological functions, including cell signaling, cell adhesion, and the structural integrity of tissues. The synthesis of iduronic acid using L-Glucurono-3,6-lactone can contribute to the development of therapeutic agents targeting conditions related to GAG deficiencies or abnormalities.
Used in Biotechnology Industry:
In the biotechnology industry, Glucuronic acid, γ-lactone, L(8CI) is utilized as a building block for the production of various bioactive molecules and pharmaceutical compounds. Its unique structure allows for the creation of novel molecules with potential applications in drug discovery and development, as well as in the design of biomaterials for tissue engineering and regenerative medicine.
Used in Chemical Synthesis:
Glucuronic acid, γ-lactone, L(8CI) is also used as a versatile starting material for the synthesis of a wide range of chemical compounds, including complex carbohydrates, glycosides, and other biologically active molecules. Its ability to undergo various chemical reactions makes it a valuable tool in the field of organic chemistry and synthetic biology.

Upstream product

• 70332-45-5 L-glucuronic acid 
• 1595285-45-2 methyl 2,3:4,5-di-O-isopropylidene-L-glucuronate 
• 102681-51-6 L-mannuronic acid 
• 576-37-4 glucuronic acid 
• 50-99-7 D-glucose 

Relevant academic research and scientific papers

Short and sweet: D-glucose to L-glucose and L-glucuronic acid

The scarcity and expense of access to L-sugars and other rare sugars have prevented the exploitation of their biological potential; for example D-psicose, only recently available, has been recognized as an important new food. Here we give the definitive and cheap synthesis of 99.4% pure L-glucose from D-glucose which requires purification of neither intermediates nor final product other than extraction into and removal of solvents; a simple crystallization will raise the purity to >99.8%. Short and sweet: The synthesis of 99.4 % pure L-glucose and L-glucuronic acid from D-glucose via very inexpensive sodium glucoheptonate requires no purification of either intermediates or final products, other than extraction into and removal of solvents; a simple crystallization will raise the purity to >99.8 %. New diacetonides of glucose and glucuronolactone are reported. Copyright

Quantitative Determination of Pt- Catalyzed d -Glucose Oxidation Products Using 2D NMR

Quantitative correlative 1H-13C NMR has long been discussed as a potential method for quantifying the components of complex reaction mixtures. Here, we show that quantitative HMBC NMR can be applied to understand the complexity of the catalytic oxidation of glucose to glucaric acid, which is a promising bio-derived precursor to adipic acid, under aqueous aerobic conditions. It is shown through 2D NMR analysis that the product streams of this increasingly studied reaction contain lactone and dilactone derivatives of acid products, including glucaric acid, which are not observable/quantifiable using traditional chromatographic techniques. At 98% glucose conversion, total C6 lactone yield reaches 44%. Furthermore, a study of catalyst stability shows that all Pt catalysts undergo product-mediated chemical leaching. Through catalyst development studies, it is shown that sequestration of leached Pt can be achieved through use of carbon supports.