3245-54-3

Upstream product

• 857231-77-7 3-(2,6-dimethyl-phenoxy)-propan-1-ol 
• 576-26-1 2.6-dimethylphenol 
• 109-64-8 1,3-dibromo-propane 
• 109-70-6 1.3-chlorobromopropane 

Downstream Products

• 806600-92-0 [3-(2,6-dimethyl-phenoxy)-propyl]-propyl-amine 
• 14573-12-7 [3-(2,6-Dimethyl-phenoxy)-propyl]-hydrazine 
• 93994-29-7 [4-(3-Bromo-propoxy)-3,5-dimethyl-phenyl]-phenyl-methanone 
• 91553-71-8 [3-(2,6-Dimethyl-phenoxy)-propyl]-methyl-amine 
• 1227359-53-6 C₁₇H₂₈N₂O₂ 
• 1227359-55-8 C₂₂H₃₀N₂O 
• 1227359-54-7 C₂₁H₂₇FN₂O 
• 1434603-58-3 (R)-N-[3-(2,6-dimethyl-phenoxy)propyl]-(1-naphthalen-1-ylethyl)-amine hydrochloride salt 
• 1434603-55-0 (R)-N-[3-(2,6-dimethyl-phenoxy)propyl]-(1-naphthalen-1-ylethyl)-amine 
• 1350302-29-2 1-[3-(2,6-dimethylphenoxy)propyl]-4-(2-methoxyphenyl)piperazine hydrochloride 
• 2299-55-0 N-<2-(2-Methoxy-phenoxy)-aethyl>-3-(2,6-dimethyl-phenoxy)-propylamin 
• 73446-33-0 1-[3-(2,6-dimethyl-phenoxy)-propyl]-piperazine 

Relevant academic research and scientific papers

Synthesis and Investigation of S-Substituted 2-Mercaptobenzoimidazoles as Inhibitors of Hedgehog Signaling

Due to the arising resistance of common drugs targeting the Hedgehog signaling pathway, the identification of new compound classes with inhibitory effect is urgently needed. We were able to identify S-alkylated 2-mercaptobenzoimidazoles as a new compound

Curcumin derivative and preparation method and application thereof

The invention relates to the field of medicinal chemistry and discloses a synthesis method of a curcumin derivative (I) and application thereof to preparation of a near-infrared small-molecule probe used for early diagnosis of the Alzheimer's disease. Experiments prove that the related compound has good selectivity on soluble Abeta, fluorescence intensity is obviously enhanced after the compound is combined with the soluble Abeta, and the most potential near-infrared fluorescent small-molecule probe with soluble Abeta selectivity has the selectivity on soluble Abeta. The molecular formula is described in the description.

Asymmetric synthesis of nonracemic primary amines via spiroborate-catalyzed reduction of pure (E)- and (Z)-O-benzyloximes: Applications toward the synthesis of calcimimetic agents

Highly enantiopure (1-aryl)- and (1-naphthyl)-1-ethylamines were synthesized by the borane-mediated reduction of single-isomeric (E)- and (Z)-O-benzyloxime ethers using the stable spiroborate ester derived from (S)-diphenyl valinol and ethylene glycol as the chiral catalyst. Primary (R)-arylethylamines were prepared by the reduction of pure (Z)-ethanone oxime ethers in up to 99% ee using 15% of catalyst. Two convenient and facile approaches to the synthesis of new and known calcimimetic analogues employing enantiopure (1-naphthalen-1-yl)ethylamine as chiral precursor are described.

Preliminary evaluation of anticonvulsant activity and neurotoxicity of some 1,4-substituted piperazine derivatives

A series of 1,4-piperazine derivatives was synthesized and evaluated for anticonvulsant activity in the maximal electroshock seizure (MES) and subcutaneous pentylenetetrazole seizure threshold (ScMet) assays and for neurotoxicity (TOX). The compounds were only moderately effective. The anticonvulsant activity was accompanied by neurotoxicity. 1-[(4-Chlor-3- methylphenoxy)-acetyl]-4-(2-methoxyphenyl)-piperazine was also evaluated in six hertz seizure test (6-Hz) and showed good activity. At the dose of 100 mg/kg b. w. the compound produced 100% protection after 0.5 h without neurotoxic effect.

Selectivity in alkylation of phenols with 1-bromo-3-chloropropane using phase-transfer catalysis

The use of various phase-transfer catalysts in the alkylation of phenol and substituted phenols with 1-bromo-3-chloropropane was investigated. When a quarternary ammonium salt of the general formula R'4N+ X-, where R' = alkyl with a minimum chain length of 4 was used, a mixture of 1-aryloxy-3-chloropropane and 1-aryloxy-3-bromopropane resulted. The effect of counterion, added potassium bromide, and catalysts other than quarternary ammonium salts were assessed for the halopropylation of 2,5-dimethylphenol.