324521-72-4Relevant academic research and scientific papers
Synthesis of 4-arylaminoquinazolines and 2-aryl-4-arylaminoquinazolines from 2-aminobenzonitrile, anilines and formic acid or benzaldehydes
Szczepankiewicz, Wojciech,Suwiński, Jerzy,Bujok, Robert
, p. 9343 - 9349 (2007/10/03)
2-Aminobenzonitrile treated with anilines in the presence of aluminium chloride gave respective 2-amino-N-arylbenzamidines. 4-Arylaminoquinazolines lacking a substituent at the 2 position were obtained directly by heating 2-amino-N-arylbenzamidines in formic acid; in similar conditions other carboxylic acids did not react with the amidines. The latter when treated with aldehydes afforded 2-aryl-4-arylimino-1H-2,3-dihydroquinazolines readily oxidizable by potassium permanganate to 2-aryl-4-arylaminoquinazolines. (C) 2000 Elsevier Science Ltd.
