324541-81-3

Upstream product

• 59340-69-1 1-((3aS,4S,6R,6aR)-6-Hydroxymethyl-2,2-dimethyl-tetrahydro-cyclopenta[1,3]dioxol-4-yl)-ethane-1,2-diol 
• 120424-51-3 (+)-(1R,4R)-4-(dimethyl-t-butylsiloxymethyl)-2β,3β-(isopropylidenedioxy)cyclopentane-β-carbaldehyde dimethyl acetal 
• 120615-61-4 ((1S,2S,3R,4R)-2,3-Diacetoxy-4-acetoxymethyl-cyclopentyl)-acetic acid 
• 111998-81-3 methyl 2-(2α,3α-diacetoxy-4β-acetoxymethylcyclopent-1β-yl)acetate 
• 111998-79-9 di-l-menthyl 2-(2α,3α-dihydroxy-di-O-isopropylidene-4β-hydroxymethylenecyclopent-1β-yl)malonate 
• 111998-78-8 di-l-menthyl 3-acetoxy-5,6-exo-dihydroxy-di-O-isopropylidenebicyclo<2.2.1>heptane-2,2-dicarboxylate 
• 120707-15-5 (-)-(1R)-menthyl 5-exo,6-exo-(isopropylidenedioxy)-3-endo-(2-pyridinylsulphonyl)bicyclo<2.2.1>heptane-2-endo-carboxylate 
• 120521-51-9 (-)-(R_S)-menthyl 5-exo,6-exo-(isopropylidenedioxy)-3-endo-(2-pyridylsulphinyl)-bicyclo<2.2.1>heptane-2-carboxylate 
• 110522-48-0 (+)-(1R,S_S)-menthyl 3-endo-(2-pyridylsulphinyl)bicyclo-<2.2.1>hept-5-ene-2-endo-carboxylate 
• 110550-21-5 (-)-(1R)-menthyl 5-exo,6-exo-(isopropylidenedioxy)bicyclo-<2.2.1>hept-2-ene-2-carboxylate 
• 120424-44-4 (-)-(1R)-menthyl 5-exo,6-exo-(isopropylidenedioxy)bicyclo<2.2.1>heptane-2-α/β-carboxylate 
• 120521-54-2 (+)-(1S)-2-(dimethyl-t-butylsiloxy)-5-exo,6-exo-(isopropyl-idenedioxy)bicyclo<2.2.1>hept-2-ene 
• 120521-53-1 (-)-(1S)-5-exo,6-exo-(isopropylidenedioxy)bicyclo<2.2.1>heptan-2-one 
• 120424-46-6 (+)-(1R)-5-exo,6-exo-(isopropylidenedioxy)bicyclo<2.2.1>heptane-2α/β-carbaldehyde 

Relevant academic research and scientific papers

Lipase-mediated preparation of a functionalized bicyclo[3.2.1]octenone and a practical utilization

Both enantiomers of a functionalized bicyclo[3.2.1]octane molecule potentially useful as a versatile chiral building block have been prepared in enantiomerically pure forms from norbomadiene by employing lipase-mediated kinetic resolution. By transforming both enantiomers enantioconvergently into the same chiral lactone serving as the key intermediate for the synthesis of the naturally occurring carbocyclic nucleoside (-)-aristeromycin, the absolute configuration of the resolved products has been established and at the same time their synthetic potential has been demonstrated.

AN ENANTIOCONVERGENT ROUTE TO CARBOCYCLIC NUCLEOSIDES (-)-ARISTEROMYCIN AND (-)-NEPLANOCIN A VIA THE ASYMMETRIC DIELS-ALDER REACTION

The asymmetric Diels-Alder reaction of (SS)-menthyl-3-(2-pyridylsulphinyl)acrylate (4) with cyclopentadiene gave almost a pure single diastereoisomeric cycloadduct.The cycloadduct was then converted into the central intermediate (+)-(3) which w

Titanium Tetrachloride-Mediated Diels-Alder Reactions of Cyclopentadiene with Di-l-menthyl Methylenemalonate and Its Acetoxy Derivative as New Chiral Dienophiles for Asymmetric Induction

Asymmetric synthesis of -2,3-dihydroxy-4-hydroxymethylcyclopent-1ylmalonate (its racemic form is already known as a versatile building block for carbocyclic C-nucleosides) was achieved by Diels-Alder reaction of cyclopentadiene with di-l-ment

Di-l-menthyl (Acetoxymethylene)malonate, a New Chiral Dienophile: Enantioselective Route to Carbocyclic Analogues of C-Nucleoside

Titanium tetrachloride promoted Diels-Alder reaction of new chiral dienophile, di-l-menthyl (acetoxymethylene)malonate, with cyclopentadiene not only proceeds with high diastereofacial selectivity but also provides an efficient enantioselective synthetic