32464-39-4

Usage

Uses

Used in Bioimaging Applications:
2,4-DIMETHYL DEUTEROPORPHYRIN IX DIMETHYL ESTER is used as a fluorescent probe for bioimaging due to its fluorescent properties. It aids in visualizing cellular structures and processes, providing valuable insights into biological systems.
Used in Photodynamic Therapy:
In the medical field, 2,4-DIMETHYL DEUTEROPORPHYRIN IX DIMETHYL ESTER is utilized as a photosensitizer in photodynamic therapy for cancer treatment. It is activated by light, generating reactive oxygen species that can kill cancer cells while minimizing damage to surrounding healthy tissue.
Used in Research and Development:
2,4-DIMETHYL DEUTEROPORPHYRIN IX DIMETHYL ESTER is employed in research and development for its unique chemical and physical properties. It serves as a valuable tool for studying porphyrin chemistry, photochemistry, and the development of new applications in various fields.
Used in Chemical Synthesis:
In the chemical industry, 2,4-DIMETHYL DEUTEROPORPHYRIN IX DIMETHYL ESTER is used as a starting material or intermediate in the synthesis of other porphyrin-based compounds. Its versatile structure allows for the development of new compounds with tailored properties for specific applications.

Upstream product

• 73061-54-8 4,5-bis(2-methoxycarbonylethyl)-1',1,2,3,6,7,8,8'-octamethyl-a,c-biladiene dihydrobromide 
• 18818-25-2 methyl 3-(5-formyl-2,4-dimethyl-1H-pyrrol-3-yl)propanoate 
• 5109-25-1 3,3'4,4'-tetramethyl-2,2'-dipyrrylmethane 
• 32045-31-1 3,3',4,4',5,5'-hexamethyl-2,2'-dipyrrolylmethene hydrobromide 
• 67-56-1 methanol 
• 78986-42-2 3,8-Dimethyl-deuteroporphyrin 

Relevant academic research and scientific papers

Cyclizations of 1',8'-Dimethyl-a,c-biladiene Salts to give Porphyrins: A Study With Various Oxidizing Agents

Cyclizations of the a,c-biladiene salts (3) and (4) to give the porphyrins (5) and (6), respectively, have been studied in the presence of a variety of chelating agents and oxidants.As a standard, the established procedure gave compounds (5) and (6), in 37 and 20percent yields repectively.Using zinc(II) acetate as a chelating agent for the a,c-biladienes, a large number of oxidants have been studied (in place of the copper chloride); best yields of porphyrin were obtained with potassium chromate and silver iodate .Other oxidants gave moderate yields of porphyrin, and others (Table 1) gave either a trace of porphyrin, or none at all.In a useful modification of the copper(II) chloride cyclization, a,c-biladienes have been cyclized during 2 h at room temperature to give porphyrins in yields of 34-65percent after removal of chelated copper.

Syntheses of Methyl-devinylporphyrins Related to Protoporphyrin -IX. Initial Studies on the Mechanism of the Copper(II) Catalysed Cyclization of 1',8'-Dimethyl-a,c-biladiene Salts

Using copper(II) catalysed cyclization of a,c-biladiene dihydrobromide salts, porphyrins related to protoporphyrin-IX dimethyl ester (8), but in which both vinyls are replaced with methyls, or where either the 2- or 4-vinyls are individually replaced with methyls, are synthesized.These compounds are required for reconstitution of the corresponding hemes into hemoproteins, to enable the study of the rotational disorder of prosthetic heme groups in reconstituted hemoproteins.By way of 13C n.m.r. spectroscopy of enriched a,c-biladienes and porphyrins, the copper(II) catalysed cyclization of 1',8'-dimethyl-a,c-biladiene dihydrobromides is shown to afford porphyrins in which one of the 1'- and 8'-methyl groups becomes the new linking meso carbon atom.

Electronic and steric factors affecting ligand binding: horse hemoglobins containing 2,4 dimethyldeuteroheme and 2,4 dibromodeuteroheme

Horse globin has been recombined with 2,4-dimethyldeuteroheme and 2,4-dibromodeuteroheme to yield the corresponding reconstituted hemoglobins, and the ligand binding reactions of these reconstituted hemoglobins have been examined in detail. Both hemoglobins exhibit relatively high n values, but 2,4-dimethyldeuterohemoglobin displays a consistently higher oxygen affinity than native hemoglobin, whereas the oxygen affinity of 2,4-dibromodeuterohemoglobin is consistently lower than that of native hemoglobin. The rate constants 1'1 and 1'4 for the binding of the first and fourth molecules of CO, respectively, for both reconstituted hemoglobins are not markedly different from those of native hemoglobin. In contrast, the kinetic rate constants for oxygen dissociation from these hemoglobins are appreciably altered. The rate constants for oxygen dissociation in the presence of dithionite for 2,4-dimethyl- and 2,4-dibromodeuterohemoglobin are 8 s-1 and 72 s-1, respectively; the corresponding rate constant for native hemoglobin is 33 s -1. Analogous results were obtained for the dissociation of oxygen in the presence of dithionite and CO. The pK of the acid-alkaline transition in the Met forms of the two reconstituted hemoglobins (pK') was also appreciably different for 2,4-dimethyl- and 2,4-dibromodeuterohemoglobin. A linear free energy relationship was found between the logarithms of the rate constants for oxygen dissociation from various reconstituted hemoglobins and pK3 of the corresponding metal-free porphyrins. A similar relationship exists between pK' and pK3, although no apparent correlation was seen between the logarithms of the association rate constants for CO and pK3 of the porphyrins. The results indicate that the rate of oxygen dissociation from hemoglobin is strongly influenced by the strength of the iron-ligand bond. However, the rate of association of CO to hemoglobin is relatively insensitive to the strength of this bond, and is probably controlled by steric effects in the ligand pocket of hemoglobin.