324740-34-3Relevant academic research and scientific papers
An improved synthesis of methyl protodioscin: Tautomerization and direct access to the 3-o-substituted kryptogenin
Xu, Qing-Chun,Liu, Yang,Liu, Jiao,He, Chun-Xian,Yan, Mao-Cai,Cheng, Mao-Sheng
, p. 780 - 781 (2008/12/21)
The acid-catalyzed tautomerization of 3-O-substituted kryptogenin 2 was studied, and the effects of acids such as silica gel, TMSOTf, acetic acid, and CDCl3, are discussed. Additionally, a Zn/KI/HOAc reduction based on this tautomerization was adopted, which afforded 2 directly, and provided a facile procedure for the synthesis of methyl protodioscin and other furostanol saponins in a mild way. Copyright
Chemical intertransformations of diverse bisdesmosidic furostanol saponins
Zhao, Dong-Mei,Liu, Yang,Liu, Yong-Xiang,Zheng, Li-Gang,Yan, Mao-Cai,Cheng, Mao-Sheng
, p. 214 - 215 (2008/02/04)
An effective synthetic route towards four types of bisdesmosidic furostanol saponin was developed and 36 derivatives were designed and synthesized for antitumor investigation. The chemical intertransformations of these furostanol structures were discussed
Total synthesis of methyl protodioscin: A potent agent with antitumor activity
Cheng, Mao S.,Wang, Qian L.,Tian, Quan,Song, Hong Y.,Liu, Yong X.,Li, Qiang,Xu, Xin,Miao, Hong D.,Yao, Xin S.,Yang, Zhen
, p. 3658 - 3662 (2007/10/03)
Methyl protodioscin (1), otherwise known as 3-O-[α-L-rhamnopyranosyl-(1→2)-{α-L-rhamnopyranosyl- (1→4)}-β-D-glucopyranosyl]-26-O-[β-D-glucopyranosyl]-22- methoxy-25(R)-furost-5-ene-3β,26-diol, has been synthesized for the first time from diosgenin through nine steps in an overall yield of 7.8%.
