324741-47-1

Upstream product

• 504-29-0 2-aminopyridine 
• 5720-07-0 4-methoxyphenylboronic acid 
• 2632-13-5 2-Bromo-4'-methoxyacetophenone 
• 31562-99-9 2-(4-methoxyphenyl)imidazo[1,2-a]pyridine 
• 98-80-6 phenylboronic acid 
• 59-88-1 phenylhydrazine hydrochloride 
• 591-50-4 iodobenzene 
• 6392-05-8 4-[(4-methoxy-phenyl)-methylsulfanyl-methylene]-morpholinium; iodide 
• 1021019-74-8 imidazo[1,2-a]pyridin-2-yl trifluoromethanesulfonate 
• 108-86-1 bromobenzene 

Relevant academic research and scientific papers

Cobalt-Catalyzed Direct Arylation of Imidazo[1,2-a]pyridine with Aryl Iodides

The Co(II)Cl2·6H2O catalyzed C–H activation/direct arylation of imidazo[1,2-a]pyridine with aryl/heteroaryl iodide is reported. The cost effective, ligand and additive free protocol using KOAc successfully afforded 3-arylimidazo[1,2-

Metal-free C-H arylation of imidazoheterocycles with aryl hydrazines

A simple and efficient metal-free arylation of imidazo[1,2-a]pyridines at the C-3 position with arylhydrazine has been achieved at room temperature under ambient air conditions. Various 2,3-disubstituted imidazopyridines and imidazothiazoles were synthesized with high yields. The present methodology demonstrates the usefulness of commercially available aryl hydrazine as an arylating agent.

An efficient access to 2,3-diarylimidazo[1,2-a]pyridines via silver(I)-catalyzed C-H bond functionalization

Abstract: An efficient and economic Ag-catalyzed method for the direct cross-coupling of unactivated imidazo[1,2-a]pyridines with arylboronic acids has been developed. This approach leads to the formation of corresponding 2,3-diarylimidazo[1,2-a]pyridine derivatives as biological and pharmaceutical materials of interest in good yields under mild reaction conditions. Graphical abstract: [Figure not available: see fulltext.].

One-step synthesis of imidazo[1,2-a] pyridines in water

A novel straightforward method for the synthesis of 2,3-disubstituted imidazo[1,2-a]pyridine derivatives in water as a truly safe and cheap reaction medium was developed. Hence, N-alkyl pyridinium and S-alkyl thiouronium salts were reacted in the presence of NaHCO3 as a mild base in water to produce imidazo[1,2-a]pyridines in moderate to excellent yields.

Straightforward synthesis of various 2,3-diarylimidazo[1,2-a]pyridines in peg400 medium through one-pot condensation and C-H arylation

PEG400 is described herein as a suitable medium for the condensation of various 2-amino pyridines with α-bromo ketones. 2-Arylimidazo[1,2-a]pyridines were synthetized in a short time through microwave irradiation in moderate to excellent yields

Synthesis and biological evaluation of 2,3-diarylimidazo[1,2-a]pyridines as antileishmanial agents

A novel series of 2,3-diarylimidazo[1,2-a]pyridines was synthesized and evaluated for their antileishmanial activities. Four derivatives exhibited good activity against the promastigote and intracellular amastigote stages of Leishmania major, coupled with a low cytotoxicity against the HeLa human cell line. The impact of compound lipophilicity on antiparasitic activities was investigated by Log D comparison. Although LmCK1 could be the parasitic target for three compounds (13, 18, 21), the inhibition of another target is under study to explain the antileishmanial effect of the most promising compounds.

An efficient access to 2,3-diarylimidazo[1,2-a]pyridines via imidazo[1,2-a]pyridin-2-yl triflate through a Suzuki cross-coupling reaction-direct arylation sequence

An efficient method to prepare 2,3-diarylimidazo[1,2-a]pyridines is described. The procedure involves a Suzuki cross-coupling reaction followed by a direct arylation at position 3. Imidazo[1,2-a]pyridin-2-yl triflate was identified as a suitable coupling partner, permitting access to a variety of highly functionalized 2,3-diarylimidazo[1,2-a]pyridines.