324761-13-9

Upstream product

• 62121-84-0 endoperoxide of 1,4-diphenylcyclopentadiene 
• 4982-34-7 1,4-diphenyl-1,3-cyclopentadiene 
• 86-98-6 4,7-dichloroquinoline 
• 5407-57-8 N-(7-chloroquinolin-4-yl)ethylenediamine 
• 324519-73-5 C₂₃H₂₂O₄ 

Relevant academic research and scientific papers

Synthesis and Antimalarial Activity of Trioxaquine Derivatives

Trioxaquines are dual molecules that contain a trioxane motif linked to an aminoquinoline entity. Among the different compounds of this series, trioxaquine cis-15 (DU1302c), prepared from α-terpinene, a cheap natural product, showed efficient antimalarial activity in vitro on both sensitive and resistant strains of Plasmodium falciparum (IC50 = 5-19 nM). A stereochemical description of this stable, nontoxic, and non-genotoxic antimalarial agent is detailed. Mice infected with P. vinckei were successfully treated with cis-15 in a four-day suppressive test. The doses required to decrease parasitemia by 50% (ED50) were 5 and 18 mg kg -1d-1 after intraperitoneal and oral administration, respectively. Parasitemia clearance was complete without recrudescence at an intraperitoneal dose of 20 mgkg-1d-1.

Dual molecules containing a peroxide derivative, synthesis and therapeutic applications thereof

The invention relates to dual molecules formed from coupling products complying with the formula wherein A represents a residue of molecule with anti-malarial activity, Y1 and Y2, represent a linear or ramified alkylene chain at C1 t