3248-41-7

Upstream product

• 626-19-7 Isophthalaldehyde 
• 46133-07-7 benzene-1,3-dicarboxladehyde dioxime 

Downstream Products

• 20723-68-6 (3,3'-m-phenylene-di-isoxazol-5-yl)-bis-methanol 
• 20723-67-5 (4,5,4',5'-tetrahydro-3,3'-m-phenylene-di-isoxazol-5-yl)-bis-methanol 
• 21154-76-7 4,5,4',5'-tetrahydro-3,3'-m-phenylene-bis-isoxazole-5-carboxylic acid diamide 
• 21154-77-8 5,5'-dimethyl-4,5,4',5'-tetrahydro-3,3'-m-phenylene-bis-isoxazole-5-carboxylic acid diamide 
• 21154-75-6 3,3'-m-phenylene-bis-isoxazole-5-carboxylic acid dimethyl ester 
• 21138-63-6 racem. 4,5,4',5'-tetrahydro-3,3'-m-phenylene-bis-isoxazole-5-carboxylic acid dimethyl ester 
• 21138-63-6 meso-4,5,4',5'-tetrahydro-3,3'-m-phenylene-bis-isoxazole-5-carboxylic acid dimethyl ester 
• 21154-78-9 5,5'-diphenyl-(3ar,6ac,3'ar',6'ac')-3a,6a,3'a,6'a-tetrahydro-3,3'-m-phenylene-bis-pyrrolo[3,4-d]isoxazole-4,6-dione 

Relevant academic research and scientific papers

Ferrocenyl bisoxazoline as an efficient non-phosphorus ligand for palladium-catalyzed copper-free Sonogashira reaction in aqueous solution

Pd(OAc)2-catalyzed Sonogashira coupling reactions of alkynes and a variety of aryl halides with 1,3-bis(5-ferrocenylisoxazoline-3-yl)benzene as an efficient non-phosphorus ligand under copper-free conditions are presented. The main advantages over previous methodologies include low catalyst loading (0.2 mol% Pd(OAc)2 and 0.4 mol% ferrocenyl bisoxazoline ligand are sufficient for these coupling reactions), less problematic reaction medium (water–dimethylformamide) and more convenient operation (no requirement for nitrogen protection).

Novel isoxazoline ligand with ferrocene backbone: Preparation and application in Heck reaction with water as solvent

Two novel isoxazoline N,N-bidentate ligands with ferrocene backbone have been synthesized and employed for the palladium-catalyzed Heck coupling reaction. Among them, 1,3-bis-(5-ferrocenylisoxazoline-3-yl)benzene was found to be thermally stable and a highly effective ligand for Heck coupling reaction in neat water without N2 protection, affording the desired coupling products in good to excellent yield with high diastereoselectivity. The developed catalytic system was also well workable for 1,2-disubstituted alkenes, which were less involved in the Heck reaction for its larger steric hindrance. Copyright