46133-07-7

Usage

Uses

Used in Coordination Compounds and Metal Complexes:
(E)-benzene-1,3-diylbis(N-hydroxymethanimine) is used as a bidentate ligand for the preparation of coordination compounds and metal complexes. Its ability to chelate with metal ions makes it a valuable component in the synthesis of these complexes, which have applications in various fields, including catalysis, materials science, and bioinorganic chemistry.
Used in Organic Dyes and Pigments:
(E)-benzene-1,3-diylbis(N-hydroxymethanimine) is also utilized in the synthesis of organic dyes and pigments. Its chemical structure contributes to the color properties of the dyes, making it a useful building block for creating a wide range of colors in the dye and pigment industry.
Used in Medicinal Chemistry:
(E)-benzene-1,3-diylbis(N-hydroxymethanimine) has potential applications in the field of medicinal chemistry. Its unique structure and properties make it a promising candidate for the development of new drugs and pharmaceuticals, particularly in the design of novel therapeutic agents.

Upstream product

• 626-19-7 Isophthalaldehyde 
• 52108-21-1 3-((hydroxyimino)methyl)benzaldehyde 
• 540-80-7 tert.-butylnitrite 
• 12129-28-1 (η6-m-xylene)tricarbonylchromium(0) 

Downstream Products

• 18728-47-7 N,N-dihydroxybenzene-1,3-dicarboximidoyl dichloride 
• 3030-54-4 1,3-benzenedicarboxylic acid dithioamide 
• 3248-41-7 isophthalonitrile N,N'-dioxide 
• 626-17-5 benzene-1,3-dicarbonitrile 
• 3441-01-8 3-cyanobenzamide 
• 287398-41-8 C₂₄H₄₀N₂O₄Si₄ 
• 7732-18-5 water 

Relevant academic research and scientific papers

BSA nanoparticles as controlled release carriers for isophethalaldoxime palladacycle complex; Synthesis, characterization,: In vitro evaluation, cytotoxicity and release kinetics analysis

A new oxime ligand named isophthalaldoxime (1) was synthesized by the addition of hydroxylamine hydrochloride to isophthalaldehyde. Then, a four nuclear palladacycle complex {Pd4[(N,C)(NOHCHC6H2CHNOH)(μ-Cl)2]su

Ferrocenyl bisoxazoline as an efficient non-phosphorus ligand for palladium-catalyzed copper-free Sonogashira reaction in aqueous solution

Pd(OAc)2-catalyzed Sonogashira coupling reactions of alkynes and a variety of aryl halides with 1,3-bis(5-ferrocenylisoxazoline-3-yl)benzene as an efficient non-phosphorus ligand under copper-free conditions are presented. The main advantages over previous methodologies include low catalyst loading (0.2 mol% Pd(OAc)2 and 0.4 mol% ferrocenyl bisoxazoline ligand are sufficient for these coupling reactions), less problematic reaction medium (water–dimethylformamide) and more convenient operation (no requirement for nitrogen protection).

Novel isoxazoline ligand with ferrocene backbone: Preparation and application in Heck reaction with water as solvent

Two novel isoxazoline N,N-bidentate ligands with ferrocene backbone have been synthesized and employed for the palladium-catalyzed Heck coupling reaction. Among them, 1,3-bis-(5-ferrocenylisoxazoline-3-yl)benzene was found to be thermally stable and a highly effective ligand for Heck coupling reaction in neat water without N2 protection, affording the desired coupling products in good to excellent yield with high diastereoselectivity. The developed catalytic system was also well workable for 1,2-disubstituted alkenes, which were less involved in the Heck reaction for its larger steric hindrance. Copyright

A versatile and green mechanochemical route for aldehyde-oxime conversions

A robust, facile and solvent-free mechanochemical path for aldehyde-oxime transformations using hydroxylamine and NaOH is explored; the method is suitable for aromatic and aliphatic aldehydes decorated with a range of substituents. This journal is

Synthesis of isoxazoles by hypervalent iodine-induced cycloaddition of nitrile oxides to alkynes

Treatment of oximes with hypervalent iodine leads to substituted isoxazoles via rapid formation of nitrile oxides. Reaction with terminal alkynes led to a series of 3,5-disubstituted isoxazoles with complete regioselectivity and high yield, in a procedure

Carbohydrate-based spiro bis(isoxazolines): synthesis and evaluation in asymmetric catalysis

Two carbohydrate-based spiro bis(isoxazolines) were synthesized via 1,3-dipolar cycloaddition from peracetylated methylene exo-glucal and the corresponding bis(arylnitrile oxide). The bis(cycloadducts) were then evaluated as ligands for enantioselective catalytic reactions. The Pd-catalyzed Tsuji-Trost reaction between a malonate and an allylic acetate did not provide good results. The poor conversion observed can be attributed to the rearrangement of the ligand in the reaction mixture to afford the corresponding ring-opened isoxazole which has been characterized. Both ligands were also evaluated in Cu(I)-catalyzed asymmetric imine alkynylation and afforded the product in good yield and modest enantioselectivity.

Synthesis of 1,3- and 1,4-bis(3-nitrofurazan-4-yl)benzenes and isomeric 1,3- and 1,4-bis[3(4)-nitrofuroxan-4(3)-yl]benzenes

The 1,3- and 1,4-bis(3-nitrofurazan-4-yl)benzenes have been synthesized by dehydration of 1,3- and 1,4-bis(2-aminoglyoximo- 1-yl)benzenes followed by oxidation of amino groups. The 1,3- and 1,4-bis(3-nitrofuroxan-4-yl)benzenes have been prepared by nitroz

ZnO/CH3COCl: A new and highly efficient catalyst for dehydration of aldoximes into nitriles under solvent-free condition

A rapid and efficient synthesis of nitriles via dehydration from the corresponding aldoximes has been carried out in the presence of ZnO/CH 3COCl as catalyst under solvent free conditions in 83-95% yields. The zinc oxide (ZnO) powder can be re-used upto three times after simple washing with CH2Cl2.

Multiple Cycloadditive macrocyclization: An Efficient Method for Crown Ether-Type Cyclophanes, Bis-Calix[4]arenes and Silamacrocycles

Macrocycles constitute a broad spectrum of compounds, which play a significant role in host-guest supramolecular chemistry. We have rationally designed an efficient novel synthetic method to synthesize different types of artificial receptive macrocycles containing isoxazoline or isoxazole ring systems. This method involves multiple (double, triple or quadrupole) cycloadditions between bifunctional dipoles and bifunctional dipolarophiles. We have presented our synthetic results to show the ease with which this one-pot synthetic method can be extended to synthesize different types of macrocycles such as cyclophanes, bis-calix[4]arenes and silamacrocycles. Hence, with appropriate combination of bifunctional dipoles and bifunctional dipolarophiles, the ring size of macrocycles could be controlled. This multiple cycloadditive macrocyclization will be a useful arsenal for the synthesis of various macrocycles.