3249-01-2

Usage

Uses

Used in Biochemical Research:
Z-Gly-L-Tyr-OEt is used as a model compound for studying the effects of peptide interactions in biological systems. Its structure and properties allow researchers to gain insights into the behavior of natural peptides and their interactions with biological molecules.
Used in Pharmaceutical Applications:
Z-Gly-L-Tyr-OEt is used as a potential drug candidate for targeting specific receptors and enzymes. Its stability and ability to mimic natural peptides make it a promising candidate for drug development, offering valuable insights into the design of novel therapeutic agents.
Used in Drug Development:
Z-Gly-L-Tyr-OEt is used as a tool in the development of new drugs, particularly in the identification and targeting of specific receptors and enzymes. Its stability and mimicry of natural peptides contribute to the advancement of pharmaceutical research and the creation of innovative therapeutic agents.

InChI:InChI=1/C21H24N2O6/c1-2-28-20(26)18(12-15-8-10-17(24)11-9-15)23-19(25)13-22-21(27)29-14-16-6-4-3-5-7-16/h3-11,18,24H,2,12-14H2,1H3,(H,22,27)(H,23,25)

Upstream product

• 4024-42-4 1-(N-benzyloxycarbonyl-glycyloxy)-piperidine 
• 4089-07-0 L-tyrosine ethyl ester monohydrochloride 
• 1738-86-9 Z-Gly-ONp 
• 949-67-7 L-tyrosine ethyl ester 
• 87023-85-6 1-(Cbz-glycyl)-3,5-dimethylpyrazole 
• 64-17-5 ethanol 
• 19790-44-4 Cbz-Gly-Tyr-NH₂ 
• 1138-80-3 N-(Benzyloxycarbonyl)glycine 
• 77374-24-4 C₁₁H₁₆BNO₄*ClH 
• 80681-01-2 [2-Oxo-2-(2-thioxo-thiazolidin-3-yl)-ethyl]-carbamic acid benzyl ester 
• 15050-24-5 N-(benzyloxycarbonyl)glycyl chloride 
• 77374-26-6 C₂₁H₂₅BN₂O₇ 
• 76410-58-7 p-borono-L-phenylalanine 
• 3065-02-9 C₂₃H₂₀N₂O₄ 

Downstream Products

• 658-79-7 N-Gly-Tyr 
• 3561-36-2 N-[N-(N-benzyloxycarbonyl-glycyl)-L-tyrosyl]-glycine ethyl ester 
• 19790-44-4 Cbz-Gly-Tyr-NH₂ 
• 19240-28-9 N-glycyl-L-tyrosine ethyl ester 
• 53823-17-9 N-(N-benzyloxycarbonyl-glycyl)-L-tyrosine hydrazide 
• 7801-35-6 Cbz-G-Y-OH 

Relevant academic research and scientific papers

One-step C-terminal deprotection and activation of peptides with peptide amidase from stenotrophomonas maltophilia in neat organic solvent

Chemoenzymatic peptide synthesis is a rapidly developing technology for cost effective peptide production on a large scale. As an alternative to the traditional C→N strategy, which employs expensive N-protected building blocks in each step, we have investigated an N→C extension route that is based on activation of a peptide C-terminal amide protecting group to the corresponding methyl ester. We found that this conversion is efficiently catalysed by Stenotrophomonas maltophilia peptide amidase in neat organic media. The system excludes the possibility of internal peptide cleavage as the enzyme lacks intrinsic protease activity. The produced peptide methyl ester was used for peptide chain extension in a kinetically controlled reaction by a thermostable protease.

3-AMINOACYL-TETRAHYDROTHIAZOLE-2-THIONE AS AN ACTIVE AMIDE FOR PEPTIDE SYNTHESIS (I)

3-Aminoacyl-tetrahydrothiazole-2-thione can be used as an active amide for peptide synthesis.A series of peptides have been synthesized with satisfactory yields by this methods.

PLURIPOTENTIAL AMINO ACIDS I. (L)-p-DIHYDROXYBORYLPHENYLALANINE (L-Bph) AS A PRECURSOR OF L-Phe AND L-Tyr CONTAINING PEPTIDES; SPECIFIC TRITIATION OF L-Phe-CONTAINING PEPTIDES AT A FINAL STEP IN THE SYNTHESIS

p-Dihydroxyborylphenylalanine has been resolved and incorporated into simple di and tripeptides; treatment of these with hydrogen peroxide or diammino silver salts results respectively in formation of tyrosine and phenylalanine peptides.