325-62-2

Upstream product

• 321-28-8 1-fluoro-2-methoxybenzene 
• 103-80-0 phenylacetyl chloride 

Downstream Products

• 347-60-4 3-fluoro-4-hydroxy-deoxybenzoin 
• 441-53-2 2-fluoro-4-stilben-α-yl-anisole 
• 386-11-8 2-(3-fluoro-4-methoxy-phenyl)-3-phenyl-quinoline-4-carboxylic acid 
• 110345-24-9 1-(3-Fluoro-4-methoxy-phenyl)-2-phenyl-3-pyrrolidin-1-yl-propan-1-one 
• 110345-26-1 1-(3-Fluoro-4-methoxy-phenyl)-2-phenyl-3-piperidin-1-yl-propan-1-one 
• 110345-25-0 α-Phenyl-β-morpholino-(3-fluoro-4-methoxy)propiophenone 
• 110345-27-2 3-Azepan-1-yl-1-(3-fluoro-4-methoxy-phenyl)-2-phenyl-propan-1-one 
• 181696-74-2 1-(3-fluoro-4-methoxyphenyl)-2-phenyl-ethan-1-one oxime 
• 181696-78-6 3-(3-fluoro-4-methoxyphenyl)-5-methyl-4-phenylisoxazole 
• 219679-66-0 C₂₁H₂₀FNO₄ 
• 181695-75-0 4-[3-(3-fluoro-4-methoxyphenyl)-5-methyl-isoxazol-4-yl]benzenesulfonamide 
• 181696-15-1 4-[5-difluoromethyl-3-(3-fluoro-4-methoxyphenyl)isoxazol-4-yl]benzenesulfonamide 
• 181697-23-4 1-(3-fluoro-4-methoxyphenyl)-2-(4-aminosulphonylphenyl)-ethan-1-one oxime 
• 181696-75-3 [3-(3-fluoro-4-methoxyphenyl)-4-phenyl-isoxazol-5-yl]propanoic acid 

Relevant academic research and scientific papers

ESTROGEN MODULATORS

The present application is directed to a new class of isoxazoles and their use as estrogen modulators.

Substituted isoxazoles for the treatment of inflammation

A class of substituted isoxazolyl compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula (III) wherein R7 is selected from hydroxyl, lower alkyl, carboxyl, halo, lower carboxylalkyl, lower alkoxycarbonylalkyl, lower alkoxyalkyl, lower carboxyalkoxyalkyl, lower haloalkyl, lower haloalkylsulfonyloxy, lower hydroxyalkyl, lower aryl (hydroxylalkyl), lower carboxyaryloxyalkyl, lower alkoxycarbonylaryloxyalkyl, lower cycloalkyl, lower cycloalkylalkyl, and lower aralkyl; and wherein R8 is one or more radicals independently selected from hydrido, lower alkylsulfinyl, lower alkyl, cyano, carboxyl, lower alkoxycarbonyl, lower haloalkyl, hydroxyl, lower hydroxyalkyl, lower haloalkoxy, amino, lower alkylamino, lower arylamino, lower aminoalkyl, nitro, halo, lower alkoxy, aminosulfonyl, and lower alkylthio; or a pharmaceutically-acceptable salt thereof.

Isoxazole compounds as cyclooxygenase inhibitors

A class of substituted isoxazolyl compounds is described for use in treating cyclooxygenase-2 related disorders. Compounds of particular interest are defined by Formula I STR1 wherein R1, R2, and R3, are described in the specification.

Synthesis and activity of sulfonamide-substituted 4,5-diaryl thiazoles as selective cyclooxygenase-2 inhibitors

A series of sulfonamide-substituted 4,5-diarylthiazoles was prepared via three synthetic routes as selective COX-2 inhibitors. Recently in the synthesis of selective COX-2 inhibitors we have discovered that the sulfonamide moiety is a suitable replacement

SUBSTITUTED ISOXAZOLES FOR THE TREATMENT OF INFLAMMATION

A class of substituted isoxazolyl compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula II wherein R1 is selected from hydroxyl, lower alkyl, carboxyl, lower carboxyalkyl, lower aminocarbonylalkyl, lower alkoxycarbonylalkyl, lower aralkyl, lower alkoxyalkyl, lower aralkoxyalkyl, lower alkylthioalkyl, lower aralkylthioalkyl, lower alkylaminoalkyl, lower aryloxyalkyl, lower arylthioalkyl, lower haloalkyl, lower hydroxylalkyl, cycloalkyl, cycloalkylalkyl, and aralkyl; wherein R3 is selected from cycloalkyl, cycloalkenyl, aryl, and heteroaryl; wherein R3 is optionally substituted at a substitutable position with one or more radicals independently selected from lower alkylsulfinyl, lower alkyl, cyano, carboxyl, lower alkoxycarbonyl, lower haloalkyl, hydroxyl, lower hydroxyalkyl, lower haloalkoxy, amino, lower alkylamino, lower arylamino, lower aminoalkyl, nitro, halo, lower alkoxy, aminosulfonyl, and lower alkylthio; and wherein R4 is selected from lower alkyl, hydroxyl and amino; or a pharmaceutically-acceptable salt thereof