32503-05-2

Upstream product

• 32503-04-1 N-(4-chlorophenyl)-N’-(4-nitrophenyl)thiourea 
• 2131-55-7 4-Chlorophenyl isothiocyanate 
• 637-87-6 1-Chloro-4-iodobenzene 
• 5901-56-4 N-4-nitrophenylguanidine 

Downstream Products

• 802328-69-4 1-sec-Butyl-3-{4-[N'-(4-chloro-phenyl)-guanidino]-phenyl}-thiourea 
• 802047-52-5 1-{4-[N'-(4-Chloro-phenyl)-guanidino]-phenyl}-3-ethyl-thiourea 
• 801213-01-4 1-{4-[N'-(4-Chloro-phenyl)-guanidino]-phenyl}-3-propyl-thiourea 
• 756414-03-6 1-{4-[N'-(4-Chloro-phenyl)-guanidino]-phenyl}-3-isobutyl-thiourea 

Relevant academic research and scientific papers

Synthesis of symmetrical and unsymmetrical N, N ′-diaryl guanidines via copper/N-methylglycine-catalyzed arylation of guanidine nitrate

CuI/N-methylglycine-catalyzed coupling reaction of guanidine nitrate with both aryl iodides and bromides takes place at 70-100 °C, affording symmetrical N,N′-diaryl guanidines with good to excellent yields. Unsymmetrical N,N′-diaryl guanidines can be assembled via monoarylation of guanidine nitrate with aryl iodides bearing a strong electron-withdrawing group and subsequent coupling with another aryl iodide.