325154-21-0

Basic information

• Product Name: ethyl 2-(4-methoxy-3-(3-methoxypropoxy)benzyl)-3-methylbutanoate
• Synonyms: ethyl 2-(4-methoxy-3-(3-methoxypropoxy)benzyl)-3-methylbutanoate
• CAS NO: 325154-21-0
• Molecular Weight: 338.444
• Mol File: 325154-21-0.mol

Chemical Properties

• CAS DataBase Reference: ethyl 2-(4-methoxy-3-(3-methoxypropoxy)benzyl)-3-methylbutanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-(4-methoxy-3-(3-methoxypropoxy)benzyl)-3-methylbutanoate(325154-21-0)
• EPA Substance Registry System: ethyl 2-(4-methoxy-3-(3-methoxypropoxy)benzyl)-3-methylbutanoate(325154-21-0)

Safety Data

• Hazardous Substances Data: 325154-21-0(Hazardous Substances Data)

Upstream product

• 325154-20-9 ethyl 2-(4-methoxy-3-(3-methoxypropoxy)benzylidene)-3-methylbutanoate 
• 325154-22-1 2-isopropyl-3-{2-[3-methoxy(propyloxy)]-4-methoxyphenyl}propionic acid 
• 1351987-20-6 C₂₁H₃₂O₅ 
• 1351987-19-3 C₂₁H₃₄O₆ 
• 109-19-3 butyl isovalerate 
• 172900-75-3 4-methoxy-3-(3-methoxypropoxy)benzaldehyde 
• 1351987-18-2 butyl-2-(4-methoxy-3-(3-methoxypropoxy)benzyl)-3-methylbutanoate 
• 64-17-5 ethanol 

Downstream Products

• 1073553-78-2 2-(4-methoxy-3-(3-methoxypropoxy)benzyl)-3-methylbutanal 
• 173338-07-3 tert-butyl (3S,5S,6S,8S)-8-(3-amino-2,2-dimethyl-3-oxopropylcarbamoyl)-6-hydroxy-3-(4-methoxy-3-(3-methoxypropoxy)benzyl)-2,9-dimethyldecan-5-ylcarbamate 
• 173334-57-1 (2S,4S,5S,7S)-5-Amino-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-8-methyl-nonanoic acid (2-carbamoyl-2-methyl-propyl)-amide 
• 945462-61-3 (R)-methyl 2-(4-methoxy-3-(3-methoxypropoxy)benzyl)-3-methylbutanoate 
• 1351987-32-0 (2R,S)(5S)-6-benzyl 1-ethyl 5-isopropyl-2-((R)-2-(4-methoxy-3-(3-methoxypropoxy)benzyl)-3-methylbutyl)-3-oxohexanedioate 
• 172900-71-9 (R)-3-[4-methoxy-3-(3-methoxypropoxy)phenyl]-2-(1-methylethyl)propanoic acid 
• 1351987-37-5 (2S,4S,5S,7S)-benzyl-4-acetoxy-5-(benzyloxycarbonylamino)-2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methylnonanoate 
• 1351987-36-4 (2S,3S,5S)-3-acetoxy-5-(benzyloxycarbonyl)-2-((R)-2-(4-methoxy-3-(3-methoxypropoxy)benzyl)-3-methylbutyl)-6-methylheptanoic acid 
• 1351987-35-3 (S,E)-3-acetoxy-5-((benzyloxy)carbonyl)-2-((S)-2-(4-methoxy-3-(3-methoxypropoxy)benzyl)-3-methylbutyl)-6-methylhept-2-enoicacid 
• 1351987-34-2 (S,E)-6-benzyl-1-tert-butyl-3-acetoxy-5-isopropyl-2-((S)-2-(4-methoxy-3-(3-methoxypropoxy)benzyl)-3-methylbutyl)hex-2-enedioate 
• 1351987-33-1 (5S)-6-benzyl-1-tert-butyl-5-isopropyl-2-((R)-2-(4-methoxy-3-(3-methoxypropoxy)benzyl)-3-methylbutyl)-3-oxohexanedioate 

Relevant articles and documents

Convergent Synthesis of the Renin Inhibitor Aliskiren Based on C5-C6 Disconnection and CO2H-NH2 Equivalence

A novel synthesis of the renin inhibitor aliskiren based on an unprecedented disconnection between C5 and C6 was developed, in which the C5 carbon acts as a nucleophile and the amino group is introduced by a Curtius rearrangement, which follows a simultaneous stereocontrolled generation of the C4 and C5 stereogenic centers by an asymmetric hydrogenation. Operational simplicity, step economy, and a good overall yield makes this synthesis amenable to manufacture on scale.

Acid promoted CIDT for the deracemization of dihydrocinnamic aldehydes with Betti's base

Racemic α-epimerizable and unfunctionalized aldehydes have been converted into enantiomerically enriched mixtures through a sequence of (i) a conversion into the diastereoisomeric 3-substituted 1-phenyl-2,3-dihydro-1H- naphtho[1,2-e][1,3]oxazines by reaction with the (R)- or (S)-1-(α- aminobenzyl)-2-naphthol (Betti's base), (ii) an acid promoted crystallization-induced diastereoisomer transformation (CIDT), and (iii) a clean cleavage of the dihydro-1,3-naphthoxazinic ring of the enriched diastereoisomer, easily collected by filtration, allowing the recovery of the enantiomerically enriched aldehydes and the chiral auxiliary.