325154-32-3Relevant articles and documents
A aliskiren or its salt separation and analysis method
-
Paragraph 0163; 0171;0172, (2017/08/25)
The invention relates to a separation analysis method using polysaccharide derivative-bonded and coated silica as a stationary phase and an organic solvent as a mobile phase for separation analysis of aliskiren and isomers thereof, effective separation of the aliskiren and isomers thereof can be realized, and the separation analysis method has the important meaning to the product quality control.
A convergent synthesis of the renin inhibitor SPP-100 using a nitrone intermediate
Dondoni, Alessandro,De Lathauwer, Geert,Perrone, Daniela
, p. 4819 - 4823 (2007/10/03)
The total synthesis of SPP-100 and its C-5 epimer involves the construction of the β-amino alcohol segment via addition of the Grignard reagent derived from 3-aryl-2-isopropyl-1-chloropropane to the nitrone functional group installed at C-4 of the pseudoe