325154-32-3

Upstream product

• 324763-51-1 aminopivalinamide 
• 437656-17-2 C₂₅H₃₂N₂O₃ 
• 393108-57-1 (3S,5R)-5-[(1S,3S)-1-bromo-3-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-4-methylpentyl]dihydro-3-isopropyl-2(3H)-furanone 
• 325740-69-0 Methanesulfonic acid (1S,3S)-1-((2S,4S)-4-isopropyl-5-oxo-tetrahydro-furan-2-yl)-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentyl ester 
• 325740-70-3 (3S,5S)-5-((1S,3S)-1-azido-3-(4-methoxy-3-(3-methoxypropoxy)benzyl)-4-methylpentyl)-3-isopropyldihydrofuran-2(3H)-one 
• 325740-67-8 (3S,5S)-dihydro-5-{(1S,3S)-1-hydroxy-3-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-4-methylpentyl}-3-(1-methylethyl)furan-2(3H)-one 
• 325740-64-5 (3S,5S)-3-Isopropyl-5-{(S)-3-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-4-methyl-pentanoyl}-dihydro-furan-2-one 
• 172900-71-9 (R)-3-[4-methoxy-3-(3-methoxypropoxy)phenyl]-2-(1-methylethyl)propanoic acid 
• 172900-70-8 (R)-2-[4-methoxy-3-(3-methoxypropoxy)benzyl]-3-methylbutanol 
• 324763-39-5 (R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane 
• 325740-58-7 (2S,4S)-4-Isopropyl-5-oxo-tetrahydro-furan-2-carboxylic acid benzyl ester 
• 325740-60-1 tetrahydro-4-isopropyl-5-oxofuran-2-carbonyl chloride 
• 325740-59-8 tetrahydro-4-isopropyl-5-oxofuran-2-carboxylic acid 
• 325740-56-5 (S)-4-Isopropyl-5-oxo-tetrahydro-furan-2-carbonyl chloride 

Relevant academic research and scientific papers

A aliskiren or its salt separation and analysis method

The invention relates to a separation analysis method using polysaccharide derivative-bonded and coated silica as a stationary phase and an organic solvent as a mobile phase for separation analysis of aliskiren and isomers thereof, effective separation of the aliskiren and isomers thereof can be realized, and the separation analysis method has the important meaning to the product quality control.

Aliskiren 5-position epimers as well as preparation method and applications thereof

The invention belongs to the field of medicine and chemical engineering and relates to aliskiren 5-position epimers as well as a preparation method and applications thereof. A molecular structure of the aliskiren 5-position epimers is represented as a formula II. The invention further relates to a preparation method of the aliskiren 5-position epimers, and the applications of the aliskiren 5-position epimers in detection of content of the aliskiren 5-position epimers in aliskiren or pharmaceutically acceptable salts of aliskiren, detection of content of impurities or optical isomers and detection of purity of aliskiren or the pharmaceutically acceptable salts of aliskiren as well as quality control for a preparation process of aliskiren or the pharmaceutically acceptable salt of aliskiren.

A convergent synthesis of the renin inhibitor SPP-100 using a nitrone intermediate

The total synthesis of SPP-100 and its C-5 epimer involves the construction of the β-amino alcohol segment via addition of the Grignard reagent derived from 3-aryl-2-isopropyl-1-chloropropane to the nitrone functional group installed at C-4 of the pseudoe

A convergent synthesis approach towards CGP60536B, a non-peptide orally potent renin inhibitor, via an enantiomerically pure ketolactone intermediate

We report a convergent synthesis of the potent orally active non-peptide renin inhibitor CGP60536B. The key reaction employs the coupling of the enantiopure Grignard species derived from chloride 13 with the diastereomerically pure γlactone 9b. The stereoselective reduction of the resulting ketone 14b has been thoroughly investigated. (C) 2000 Elsevier Science Ltd.