325172-30-3

Upstream product

• 135362-69-5 3-(4-methoxybenzyl)oxypropan-1-ol 
• 1227476-20-1 C₁₉H₃₄O₄Si 
• 325172-40-5 (R)-[1-(4-methoxybenzyloxy)-3-((tert-butyl)dimethylsilyloxy)hex-5-en-3-yloxy]dimethylsilane 
• 325172-29-0 (3R)-1-[(4-methoxybenzyl)oxy]hex-5-en-3-ol 
• 128461-65-4 3-(p-methoxybenzyloxy)propanal 

Downstream Products

• 1227476-21-2 (4R,6S)-6-(tert-butyldimethylsilyloxy)-8-(4-methoxybenzyloxy)oct-1-en-4-ol 
• 325172-41-6 (2R,3S,5S)-2-Allyl-5-(tert-butyl-dimethyl-silanyloxy)-1-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-7-(4-methoxy-benzyloxy)-3-methoxymethoxy-heptan-1-one 
• 325172-42-7 toluene-4-sulfonic acid 2-[3-(tert-butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxy)-1-methoxymethoxy-pentyl]-pent-4-enyl ester 
• 325172-33-6 2-Allyl-6-methoxy-benzoic acid (1R,3S,4R)-1-[2-(4-methoxy-benzyloxy)-ethyl]-3-methoxymethoxy-4-methyl-hept-6-enyl ester 
• 312962-27-9 (7R,9S,10R)-4-methoxy-7-[2-(4-methoxy-benzyloxy)-ethyl]-9-methoxymethoxy-10-methyl-7,8,9,10,11,14-hexahydro-6-oxa-benzocyclododecen-5-one 
• 325172-32-5 2-[3-(tert-butyl-dimethyl-silanyloxy)-5-(4-methoxy-benzyloxy)-1-methoxymethoxy-pentyl]-pent-4-en-1-ol 
• 325172-43-8 tert-Butyl-{(1S,3S,4R)-1-[2-(4-methoxy-benzyloxy)-ethyl]-3-methoxymethoxy-4-methyl-hept-6-enyloxy}-dimethyl-silane 
• 325172-27-8 (3S,5S,6R)-1-(4-Methoxy-benzyloxy)-5-methoxymethoxy-6-methyl-non-8-en-3-ol 
• 198482-00-7 (+)-Salicylihalamide A 
• 325172-31-4 (2R,3S,5S)-2-Allyl-5-(tert-butyl-dimethyl-silanyloxy)-1-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-3-hydroxy-7-(4-methoxy-benzyloxy)-heptan-1-one 

Relevant academic research and scientific papers

Byproduct formation during the biosynthesis of spinosyn A and evidence for an enzymatic interplay to prevent its formation

Biosynthesis of spinosyn A in Saccharopolyspora spinosa involves a 1,4-dehydration followed by an intramolecular [4 + 2]-cycloaddition catalyzed by SpnM and SpnF, respectively. The cycloaddition also takes place in the absence of SpnF leading to questions

A designed amide as an aldol donor in the direct catalytic asymmetric aldol reaction

The direct catalytic asymmetric aldol reaction offers efficient access to β-hydroxy carbonyl entities. Described is a robust direct catalytic asymmetric aldol reaction of α-sulfanyl 7-azaindolinylamide, thus affording both aromatic and aliphatic β-hydroxy amides with high ee values. The design of this transformation features a cooperative interplay of a soft and a hard Lewis acid, which together facilitate the challenging chemoselective enolization by a hard Bronsted base.

PTSA-catalyzed tandem cyclization protocol for the stereoselective total synthesis of obolactone

Stereoselective total synthesis of obolactone by the Br?nsted acid (PTSA) mediated tandem cyclization of the appropriately substituted diketone in one-pot in a highly selective and efficient manner is reported.

Short diastereoselective synthesis of the C1-C13 (AB Spiroacetal) and C17-C28 fragments (CD spiroacetal) of spongistatin 1 and 2 through double chain-elongation reactions

A unique and practical synthetic sequence for rapid access to polyketides and to further the spiroacetals derived from them, which utilizes a bidirectional Hosomi-Sakurai allylation approach around key allylsilanes in the synthesis of the AB and CD ring s

Revision of the absolute configuration of salicylihalamide A through asymmetric total synthesis

A highly E-selective ring-closing metathesis is the key to building the macrocyclic salicylate core of (+)-salicylihalamide A (1). The synthesis results in a reassignment of the absolute configuration of natural (-)-salicylihalamide A (2), a structurally