32539-16-5

Usage

Uses

Used in Pharmaceutical Industry:
2-(trifluoroMethyl)-5-(Methylthio)-1,3,4-thiadiazole is used as an active pharmaceutical ingredient for its antimicrobial and antifungal properties. It is employed in the development of drugs targeting a wide range of microbial infections, contributing to the treatment and prevention of various diseases caused by harmful microorganisms.
Used in Agricultural Industry:
In the agricultural sector, 2-(trifluoroMethyl)-5-(Methylthio)-1,3,4-thiadiazole is used as a herbicide. Its herbicidal properties make it an effective tool for controlling and eliminating unwanted plant species, thereby promoting the growth of desired crops and improving overall agricultural productivity.
Used in Organic Synthesis:
2-(trifluoroMethyl)-5-(Methylthio)-1,3,4-thiadiazole is utilized as a building block in the synthesis of various organic compounds. Its unique chemical structure allows it to be incorporated into a wide range of molecules, making it a valuable component in the development of new pharmaceuticals, agrochemicals, and other specialty chemicals.

InChI:InChI=1/C4H3F3N2S2/c1-10-3-9-8-2(11-3)4(5,6)7/h1H3

Upstream product

• 76-05-1 trifluoroacetic acid 
• 5397-03-5 hydrazinecarbodithioic acid methyl ester 

Downstream Products

• 65439-30-7 2-methylsulphinyl-5-trifluoromethyl-1,3,4-thiadiazole 

Relevant academic research and scientific papers

Synthetic method 2 -methylsulfonyl -5 - trifluoromethyl -1 , 3, 4 - thiadiazole

The invention belongs to the technical field of medical intermediates, and particularly relates to a synthetic method 2 -methylsulfonyl -5 - trifluoromethyl -1 , 3, 4 - thiadiazole. To the invention, hydrazine hydrate and carbon disulfide are subjected to addition reaction, and then under basic conditions, dimethyl sulfate is replaced to obtain the intermediate material A, and the intermediate material A is obtained. The intermediate material B is obtained by reacting the intermediate material B with hydrogen peroxide to obtain 2 - methylsulfonyl -5 - trifluoromethyl -1 , 3, 4 - thiadiazole, the operation is simple, the operation is easy, and the yield is high.

Flufenacet preparation method

The invention discloses a flufenacet preparation method, which comprises synthesis of 2-methylsulfonyl-5-trifluoromethyl-1,3,4-thiadiazole, synthesis of 2-hydroxy-N-(4-fluoroaniline)-N-(1-methylethyl)acetamide and synthesis of 4'-fluoro-N-isopropyl-2-[5-(trifluridine)-1,3,4-thiadiazole-2-imide]acetamide. The optimal flufenacet preparation method is screened by a large number of experiments, the whole process is reasonable in design, particularly the steps of screening optimal reaction conditions and the optimal amount ratio, reaction temperature, reaction time and the like of reaction raw materials, the reaction yield (capable of reaching 90 percent or more) can be greatly increased, side reaction can be reduced, the reaction rate can be increased, the reaction raw materials can be recycled, the production cost is greatly reduced, and a broad application prospect is achieved.

Process for making 2-(methylthio)-5-(trifluoromethyl)-1,3,4-thiadiazole using methyldithiocarbazinate with trifluoroacetic acid with selective removal of 2,5-bis(methylthio)-1,3,4-thiadiazole

The present invention provides a process for making 2-(methylthio)-5-(trifluoromethyl)-1,3,4-thiadiazole. The process includes the steps of reacting methyidithiocarbazinate with trifluoroacetic acid, in the absence of phosphorus trichloride, to form a mixture of 2-(methylthio)-5-(trifluoromethyl)-1,3,4-thiadiazole and 2,5-bis-(methylthio)-1,3,4-thiadiazole. Further, the process of the present invention includes selectively removing the 2,5-bis-(methylthio)-1,3,4-thiadiazole by acidifying the reaction mixture, and then separating the aqueous and organic phases.

Process for preparing 2-(methylthio)-5-(trifluoromethyl) -1,3,4-thiadiazole using methyldithiocarbazinate and a molar excess of trifluoroacetic acid with recovery of trifluoroacetic acid

The present invention provides a process for preparing 2-(methylthio)-5-(trifluoromethyl)-1,3,4-thiadiazole. The process includes the steps of reacting methyldithiocarbazinate with a molar excess of trifluoroacetic acid and recovering the excess trifluoroacetic acid.

Preparation of heteroaryloxyacetamides

A process for the preparation of a heteroaryloxyacetamide of the formula STR1 in which R is a 5 membered heterocycle which may be benzo-fused, and R1 and R2 each independently is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl or cyclo