32539-16-5

Basic information

• Product Name: 2-(trifluoroMethyl)-5-(Methylthio)-1,3,4-thiadiazole
• Synonyms: 2-(trifluoroMethyl)-5-(Methylthio)-1,3,4-thiadiazole;2-(Methylthio)-5-(trifluoromethyl)-1,3,4-thiadiazole;2-Methylsulfanyl-5-trifluoromethyl-[1,3,4]thiadiazole
• CAS NO: 32539-16-5
• Molecular Formula: C4H3F3N2S2
• Molecular Weight: 200.2052296
• Mol File: 32539-16-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 197℃
• Flash Point: 73℃
• Appearance: /
• Density: 1.55
• Vapor Pressure: 0.552mmHg at 25°C
• Refractive Index: 1.506
• PKA: -2.85±0.10(Predicted)
• CAS DataBase Reference: 2-(trifluoroMethyl)-5-(Methylthio)-1,3,4-thiadiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(trifluoroMethyl)-5-(Methylthio)-1,3,4-thiadiazole(32539-16-5)
• EPA Substance Registry System: 2-(trifluoroMethyl)-5-(Methylthio)-1,3,4-thiadiazole(32539-16-5)

Safety Data

• Hazardous Substances Data: 32539-16-5(Hazardous Substances Data)

Usage

General Description

2-(trifluoroMethyl)-5-(Methylthio)-1,3,4-thiadiazole is a chemical compound that belongs to the thiadiazole family. It is a white to pale yellow solid with the molecular formula C5H4F3N3S. 2-(trifluoroMethyl)-5-(Methylthio)-1,3,4-thiadiazole is used in the pharmaceutical and agricultural industries for its potential biological activities. It has been studied for its antimicrobial, antifungal, and herbicidal properties. Additionally, it has been investigated for its potential use as a building block in the synthesis of various organic compounds. Overall, 2-(trifluoroMethyl)-5-(Methylthio)-1,3,4-thiadiazole is a versatile chemical with diverse potential applications.

InChI:InChI=1/C4H3F3N2S2/c1-10-3-9-8-2(11-3)4(5,6)7/h1H3

Upstream product

• 5397-03-5 hydrazinecarbodithioic acid methyl ester 
• 76-05-1 trifluoroacetic acid 

Downstream Products

• 65439-30-7 2-methylsulphinyl-5-trifluoromethyl-1,3,4-thiadiazole 

Relevant articles and documents

Synthetic method 2 -methylsulfonyl -5 - trifluoromethyl -1 , 3, 4 - thiadiazole

The invention belongs to the technical field of medical intermediates, and particularly relates to a synthetic method 2 -methylsulfonyl -5 - trifluoromethyl -1 , 3, 4 - thiadiazole. To the invention, hydrazine hydrate and carbon disulfide are subjected to addition reaction, and then under basic conditions, dimethyl sulfate is replaced to obtain the intermediate material A, and the intermediate material A is obtained. The intermediate material B is obtained by reacting the intermediate material B with hydrogen peroxide to obtain 2 - methylsulfonyl -5 - trifluoromethyl -1 , 3, 4 - thiadiazole, the operation is simple, the operation is easy, and the yield is high.

Process for making 2-(methylthio)-5-(trifluoromethyl)-1,3,4-thiadiazole using methyldithiocarbazinate with trifluoroacetic acid with selective removal of 2,5-bis(methylthio)-1,3,4-thiadiazole

The present invention provides a process for making 2-(methylthio)-5-(trifluoromethyl)-1,3,4-thiadiazole. The process includes the steps of reacting methyidithiocarbazinate with trifluoroacetic acid, in the absence of phosphorus trichloride, to form a mixture of 2-(methylthio)-5-(trifluoromethyl)-1,3,4-thiadiazole and 2,5-bis-(methylthio)-1,3,4-thiadiazole. Further, the process of the present invention includes selectively removing the 2,5-bis-(methylthio)-1,3,4-thiadiazole by acidifying the reaction mixture, and then separating the aqueous and organic phases.

Preparation of heteroaryloxyacetamides

A process for the preparation of a heteroaryloxyacetamide of the formula STR1 in which R is a 5 membered heterocycle which may be benzo-fused, and R1 and R2 each independently is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl or cyclo