32543-26-3Relevant academic research and scientific papers
Method of colorimetric analysis of malonic dialdehyde and 4-hydroxy-2-enaldehydes as indexes of lipid peroxidation, kits for carrying out said method, substituted indoles for use in said method and their preparation
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, (2008/06/13)
A colorimetric assay of enaldehydes or of malonic dialdehyde as lipid peroxidation indices in an aqueous medium including a) addition to the medium of a reagent of a compound of general formula I and their optional addition salts with organic or inorganic bases or with organic or inorganic acids. STR1 in which formula: A and C, which may be identical or different, each represent H, STR2 wherein A and C cannot simultaneously represent H, with: R1 =H; alkyl; aralkyl; aryl substituted on the aryl ring; alkyl sulfonate Y+ ; alkyl phosphonate, Y+ ; or alkyl carboxylate, Y+ ; R2 =H; --OR4 ; F; Cl; Br; I; --NO2 ; SO331 Y+ ; --CN; --COOR4 ; or --CONR5 R6 ; R3 =H; --OR4 ; --NR5 R6 ; --SR4 ; F; Cl; Br; I; --NO2 ; --SO3 --Y+ ; --CN; --COR5 ; --COOR4 ; or --CONR5 R6 ; R4 =H; alkyl; aralkyl; or aryl substituted on the aryl ring; R5 =H; alkyl; aralkyl; or aryl substituted on the aryl ring; R6 =H; aryl, aralkyl; or aryl substituted on the aryl ring; Y+ =cation of an organic or inorganic base; STR3 wherein alkyl represents a linear or branched group comprising 1 to 6 carbon; aryl is substituted on the aryl ring with one or more groups which may be identical or different selected from C1-6 alkyl, alkoxy, hydroxy, amino and carboxyl; b) acidification of the medium; and c) incubation of the acidified medium. Requisites or kits for the implementation of the process are also disclosed.
