325464-24-2Relevant academic research and scientific papers
Inhibition of (cytosine C5)-methyltransferase by oligonucleotides containing flexible (cyclopentane) and conformationally constrained (bicyclo[3.1.0]hexane) abasic sites
Marquez,Wang,Nicklaus,Maier,Manoharan,Christman,Banavali,Mackerell A.D.
, p. 451 - 459 (2007/10/03)
Pseudorotationally locked sugar analogues based on bicyclo[3.1.0]-hexane templates were placed in DNA duplexes as abasic target sites in the M.HhaI recognition sequence. The binding affinity of the enzyme increases when the abasic site is constrained to t
Use of oligodeoxyribonucleotides with conformationally constrained abasic sugar targets to probe the mechanism of base flipping by hhaI DNA (cytosine C5)-methyltransferase
Wang,Brank,Banavali,Nicklaus,Marquez,Christman,Mackerell, Jr.
, p. 12422 - 12434 (2007/10/03)
X-ray crystallographic studies of HhaI DNA (cytosine-C5)-methyltransferase (M.HhaI) covalently linked to methylated 5-fluorocytosine in DNA provided the first direct evidence that the cytosine residue targeted for methylation was "flipped" out of the heli
