32548-29-1Relevant academic research and scientific papers
Selective Friedel-Crafts Acylation Reactions of 2-Arylphenoxyacetic Acids: A Simple and Efficient Methodology to Synthesize Dibenzoxepine and Arylcoumaranone Derivatives
Wang, Jialin,Liu, Jiaqi,Lan, Hao,Chu, Wenyi,Sun, Zhizhong
, p. 3049 - 3060 (2015)
Intramolecular Friedel-Crafts acylation reactions of 2-arylphenoxyacetic acids are accomplished using trifluoroacetic anhydride or trifluoromethanesulfonic acid at 0 °C or room temperature. Depending on the reaction conditions, dibenzoxepines or arylcoumaranones are obtained in good yields and with high selectivities (83-100%). Plausible mechanistic pathways for the selective formation of the different reaction products are discussed.
