5348-75-4

Basic information

• Product Name: (BIPHENYL-2-YLOXY)-ACETIC ACID
• Synonyms: 2-(2-phenylphenoxy)acetic acid
• CAS NO: 5348-75-4
• Molecular Formula: C₁₄H₁₂O₃
• Molecular Weight: 228.25
• Mol File: 5348-75-4.mol
• Article Data: 8

Chemical Properties

• Melting Point: 109.5-110 °C(Solv: benzene (71-43-2); ligroine (8032-32-4))
• Boiling Point: 372.9°Cat760mmHg
• Flash Point: 141.7°C
• Appearance: /
• Density: 1.202g/cm³
• Vapor Pressure: 3.21E-06mmHg at 25°C
• Refractive Index: 1.586
• PKA: 3.16±0.10(Predicted)
• CAS DataBase Reference: (BIPHENYL-2-YLOXY)-ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (BIPHENYL-2-YLOXY)-ACETIC ACID(5348-75-4)
• EPA Substance Registry System: (BIPHENYL-2-YLOXY)-ACETIC ACID(5348-75-4)

Safety Data

• Hazardous Substances Data: 5348-75-4(Hazardous Substances Data)

Usage

General Description

(BIPHENYL-2-YLOXY)-ACETIC ACID is a chemical compound with the molecular formula C14H12O3. It is an aromatic carboxylic acid that contains a biphenyl group attached to an acetic acid moiety. (BIPHENYL-2-YLOXY)-ACETIC ACID has potential applications in organic synthesis and pharmaceutical research. It is a white solid with a melting point of 108-110°C. "(BIPHENYL-2-YLOXY)-ACETIC ACID" is used as a building block for the synthesis of various organic compounds and has been studied for its potential biological activities.

InChI:InChI=1/C14H12O3/c15-14(16)10-17-13-9-5-4-8-12(13)11-6-2-1-3-7-11/h1-9H,10H2,(H,15,16)

Upstream product

• 95-56-7 2-hydroxybromobenzene 
• 107352-46-5 ethyl (<1,1'-biphenyl>-2-yloxy)acetate 
• 98-80-6 phenylboronic acid 
• 90841-62-6 ethyl 2-(2-bromophenoxy)acetate 
• 90-43-7 2-Phenylphenol 
• 188646-07-3 ([1,1′-biphenyl]-2-yloxy)(tert-butyl)dimethylsilane 
• 115750-83-9 (2-bromophenoxy)(tert-butyl)dimethylsilane 
• 79-08-3 bromoacetic acid 
• 473678-92-1 (biphenyl-2-yloxy)acetic acid benzyl ester 
• 105-36-2 ethyl bromoacetate 
• 305129-29-7 methyl 2-(biphenyl-2-yloxy)acetate 
• 79-11-8 chloroacetic acid 

Downstream Products

• 90-43-7 2-Phenylphenol 
• 32548-29-1 6,7-dihydro-dibenzoxepin-6-one 

Relevant articles and documents

Selective Friedel-Crafts Acylation Reactions of 2-Arylphenoxyacetic Acids: A Simple and Efficient Methodology to Synthesize Dibenzoxepine and Arylcoumaranone Derivatives

Intramolecular Friedel-Crafts acylation reactions of 2-arylphenoxyacetic acids are accomplished using trifluoroacetic anhydride or trifluoromethanesulfonic acid at 0 °C or room temperature. Depending on the reaction conditions, dibenzoxepines or arylcoumaranones are obtained in good yields and with high selectivities (83-100%). Plausible mechanistic pathways for the selective formation of the different reaction products are discussed.

Direct C-F bond formation using photoredox catalysis

We have developed the first example of a photoredox catalytic method for the formation of carbon-fluorine (C-F) bonds. The mechanism has been studied using transient absorption spectroscopy and involves a key single-electron transfer from the 3MLCT (triplet metal-to-ligand charge transfer) state of Ru(bpy)32+ to Selectfluor. Not only does this represent a new reaction for photoredox catalysis, but the mild reaction conditions and use of visible light also make it a practical improvement over previously developed UV-mediated decarboxylative fluorinations.

THIADIAZOLE DERIVATIVES, INHIBITORS OF STEAROYL-COA DESATURASE

The present invention relates to substituted thiadiazole compounds of the formula (I) and pharmaceutically acceptable salts thereof, to pharmaceutical compositions containing them and their use in medicine. In particular, the invention relates to compounds for modulating SCD activity.